Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates.

J. R. Higgins, S. Sutjipto, P. A. Marx, Niels C Pedersen

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (SIV and HIV) were compared using a panel of eleven mouse monoclonal antibodies (Mabs) that recognized nine distinct gag epitopes. Viral isolates used for comparison were HIV-1IIIb, HIV-2ROD, and SIV isolates from macaque (SIVmac), sooty mangabey (SIVsm-UCD), African green monkey (SIVagm), and stump-tailed macaque (SIVstm-UCD). The relatedness of the various HIV and SIV isolates, as determined by Mabs to core protein epitopes, paralleled that ascertained by genetic sequencing.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalJournal of Medical Primatology
Volume21
Issue number5
StatePublished - Jul 1992

Fingerprint

Viral Core Proteins
Simian immunodeficiency virus
Simian Immunodeficiency Virus
Human immunodeficiency virus
epitopes
Epitopes
HIV
monoclonal antibodies
Macaca arctoides
Cercocebus
Macaca
Cercopithecus aethiops
proteins
protein isolates
Cercocebus atys
Monoclonal Antibodies
gag Gene Products
mice
Proteins

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates. / Higgins, J. R.; Sutjipto, S.; Marx, P. A.; Pedersen, Niels C.

In: Journal of Medical Primatology, Vol. 21, No. 5, 07.1992, p. 265-269.

Research output: Contribution to journalArticle

@article{da351ad6d514452c902eec952d01928f,
title = "Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates.",
abstract = "Antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (SIV and HIV) were compared using a panel of eleven mouse monoclonal antibodies (Mabs) that recognized nine distinct gag epitopes. Viral isolates used for comparison were HIV-1IIIb, HIV-2ROD, and SIV isolates from macaque (SIVmac), sooty mangabey (SIVsm-UCD), African green monkey (SIVagm), and stump-tailed macaque (SIVstm-UCD). The relatedness of the various HIV and SIV isolates, as determined by Mabs to core protein epitopes, paralleled that ascertained by genetic sequencing.",
author = "Higgins, {J. R.} and S. Sutjipto and Marx, {P. A.} and Pedersen, {Niels C}",
year = "1992",
month = "7",
language = "English (US)",
volume = "21",
pages = "265--269",
journal = "Journal of Medical Primatology",
issn = "0047-2565",
publisher = "Blackwell Munksgaard",
number = "5",

}

TY - JOUR

T1 - Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates.

AU - Higgins, J. R.

AU - Sutjipto, S.

AU - Marx, P. A.

AU - Pedersen, Niels C

PY - 1992/7

Y1 - 1992/7

N2 - Antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (SIV and HIV) were compared using a panel of eleven mouse monoclonal antibodies (Mabs) that recognized nine distinct gag epitopes. Viral isolates used for comparison were HIV-1IIIb, HIV-2ROD, and SIV isolates from macaque (SIVmac), sooty mangabey (SIVsm-UCD), African green monkey (SIVagm), and stump-tailed macaque (SIVstm-UCD). The relatedness of the various HIV and SIV isolates, as determined by Mabs to core protein epitopes, paralleled that ascertained by genetic sequencing.

AB - Antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (SIV and HIV) were compared using a panel of eleven mouse monoclonal antibodies (Mabs) that recognized nine distinct gag epitopes. Viral isolates used for comparison were HIV-1IIIb, HIV-2ROD, and SIV isolates from macaque (SIVmac), sooty mangabey (SIVsm-UCD), African green monkey (SIVagm), and stump-tailed macaque (SIVstm-UCD). The relatedness of the various HIV and SIV isolates, as determined by Mabs to core protein epitopes, paralleled that ascertained by genetic sequencing.

UR - http://www.scopus.com/inward/record.url?scp=0026885882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026885882&partnerID=8YFLogxK

M3 - Article

C2 - 1383547

AN - SCOPUS:0026885882

VL - 21

SP - 265

EP - 269

JO - Journal of Medical Primatology

JF - Journal of Medical Primatology

SN - 0047-2565

IS - 5

ER -