Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates.

J. R. Higgins, S. Sutjipto, P. A. Marx, Niels C Pedersen

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (SIV and HIV) were compared using a panel of eleven mouse monoclonal antibodies (Mabs) that recognized nine distinct gag epitopes. Viral isolates used for comparison were HIV-1IIIb, HIV-2ROD, and SIV isolates from macaque (SIVmac), sooty mangabey (SIVsm-UCD), African green monkey (SIVagm), and stump-tailed macaque (SIVstm-UCD). The relatedness of the various HIV and SIV isolates, as determined by Mabs to core protein epitopes, paralleled that ascertained by genetic sequencing.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalJournal of Medical Primatology
Volume21
Issue number5
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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