Sex hormone levels in young Indian patients with myocardial infarction

M. Sewdarsen, I. Jialal, S. Vythilingum, R. Desai

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The finding of abnormal levels of sex hormones in men with coronary artery disease has led to the hypothesis that alterations in sex hormones may represent an important risk factor for myocardial infarction. In this study, the sex hormone profile of 28 young men (aged < 40 years) with myocardial infarction was compared with 28 age- and weight-matched normal men. Although the mean total serum estradiol levels and the free estradiol index of the patients and controls were similar, the mean serum total testosterone level and the free testosterone index were significantly lowered in the patients with myocardial infarction (p < 0.01). The ratio of serum estradiol to testosterone was significantly increased in the patients (p = 0.0005) and correlated with serum cholesterol, triglycerides, and plasma glucose. A significant inverse correlation was also demonstrated between total testosterone and serum cholesterol and triglycerides. Hence, the results of this study support the hypothesis that low plasma testosterone and an increased estradiol-to-testosterone ratio may be important risk factors for myocardial infarction.

Original languageEnglish (US)
Pages (from-to)418-421
Number of pages4
JournalArteriosclerosis
Volume6
Issue number4
StatePublished - 1986
Externally publishedYes

Fingerprint

Gonadal Steroid Hormones
Testosterone
Myocardial Infarction
Estradiol
Serum
Triglycerides
Cholesterol
Coronary Artery Disease
Weights and Measures
Glucose

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sewdarsen, M., Jialal, I., Vythilingum, S., & Desai, R. (1986). Sex hormone levels in young Indian patients with myocardial infarction. Arteriosclerosis, 6(4), 418-421.

Sex hormone levels in young Indian patients with myocardial infarction. / Sewdarsen, M.; Jialal, I.; Vythilingum, S.; Desai, R.

In: Arteriosclerosis, Vol. 6, No. 4, 1986, p. 418-421.

Research output: Contribution to journalArticle

Sewdarsen, M, Jialal, I, Vythilingum, S & Desai, R 1986, 'Sex hormone levels in young Indian patients with myocardial infarction', Arteriosclerosis, vol. 6, no. 4, pp. 418-421.
Sewdarsen M, Jialal I, Vythilingum S, Desai R. Sex hormone levels in young Indian patients with myocardial infarction. Arteriosclerosis. 1986;6(4):418-421.
Sewdarsen, M. ; Jialal, I. ; Vythilingum, S. ; Desai, R. / Sex hormone levels in young Indian patients with myocardial infarction. In: Arteriosclerosis. 1986 ; Vol. 6, No. 4. pp. 418-421.
@article{16a10cceddd64100a6d551eb01b80dea,
title = "Sex hormone levels in young Indian patients with myocardial infarction",
abstract = "The finding of abnormal levels of sex hormones in men with coronary artery disease has led to the hypothesis that alterations in sex hormones may represent an important risk factor for myocardial infarction. In this study, the sex hormone profile of 28 young men (aged < 40 years) with myocardial infarction was compared with 28 age- and weight-matched normal men. Although the mean total serum estradiol levels and the free estradiol index of the patients and controls were similar, the mean serum total testosterone level and the free testosterone index were significantly lowered in the patients with myocardial infarction (p < 0.01). The ratio of serum estradiol to testosterone was significantly increased in the patients (p = 0.0005) and correlated with serum cholesterol, triglycerides, and plasma glucose. A significant inverse correlation was also demonstrated between total testosterone and serum cholesterol and triglycerides. Hence, the results of this study support the hypothesis that low plasma testosterone and an increased estradiol-to-testosterone ratio may be important risk factors for myocardial infarction.",
author = "M. Sewdarsen and I. Jialal and S. Vythilingum and R. Desai",
year = "1986",
language = "English (US)",
volume = "6",
pages = "418--421",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Sex hormone levels in young Indian patients with myocardial infarction

AU - Sewdarsen, M.

AU - Jialal, I.

AU - Vythilingum, S.

AU - Desai, R.

PY - 1986

Y1 - 1986

N2 - The finding of abnormal levels of sex hormones in men with coronary artery disease has led to the hypothesis that alterations in sex hormones may represent an important risk factor for myocardial infarction. In this study, the sex hormone profile of 28 young men (aged < 40 years) with myocardial infarction was compared with 28 age- and weight-matched normal men. Although the mean total serum estradiol levels and the free estradiol index of the patients and controls were similar, the mean serum total testosterone level and the free testosterone index were significantly lowered in the patients with myocardial infarction (p < 0.01). The ratio of serum estradiol to testosterone was significantly increased in the patients (p = 0.0005) and correlated with serum cholesterol, triglycerides, and plasma glucose. A significant inverse correlation was also demonstrated between total testosterone and serum cholesterol and triglycerides. Hence, the results of this study support the hypothesis that low plasma testosterone and an increased estradiol-to-testosterone ratio may be important risk factors for myocardial infarction.

AB - The finding of abnormal levels of sex hormones in men with coronary artery disease has led to the hypothesis that alterations in sex hormones may represent an important risk factor for myocardial infarction. In this study, the sex hormone profile of 28 young men (aged < 40 years) with myocardial infarction was compared with 28 age- and weight-matched normal men. Although the mean total serum estradiol levels and the free estradiol index of the patients and controls were similar, the mean serum total testosterone level and the free testosterone index were significantly lowered in the patients with myocardial infarction (p < 0.01). The ratio of serum estradiol to testosterone was significantly increased in the patients (p = 0.0005) and correlated with serum cholesterol, triglycerides, and plasma glucose. A significant inverse correlation was also demonstrated between total testosterone and serum cholesterol and triglycerides. Hence, the results of this study support the hypothesis that low plasma testosterone and an increased estradiol-to-testosterone ratio may be important risk factors for myocardial infarction.

UR - http://www.scopus.com/inward/record.url?scp=0022535184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022535184&partnerID=8YFLogxK

M3 - Article

C2 - 3729798

AN - SCOPUS:0022535184

VL - 6

SP - 418

EP - 421

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 4

ER -