Sex differences in the treatment of Psoriatic Arthritis: A systematic literature review

Elena Generali, Carlo A. Scirè, Luca Cantarini, Carlo Selmi

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory condition associated with skin psoriasis and manifests a wide clinical phenotype, with proposed differences between sexes. Current treatments are based on traditional disease-modifying antirheumatic drugs (DMARD), and biologic agents and studies have reported different clinical response patterns depending on sex factors. We aimed to identify sex differences in drug retention rate in patients with PsA and performed a systematic research on MEDLINE, EMBASE and Cochrane databases (1979 to June 2015) for studies regarding effectiveness (measured as drug retention rate) in PsA in both traditional DMARDs and biologics. Demographic data as well as retention rates between sexes were extracted. From a total 709 retrieved references, we included 9 articles for the final analysis. Only one study reported data regarding DMARDs, while eight studies reported retention rate for anti-tumor necrosis factor (TNF) biologics, mainly infliximab, adalimumab and etanercept. No differences were reported in retention rates between sexes for methotrexate, while women manifested lower retention rates compared to men with regard to anti-TNF. We highlight the need to include sex differences in the management flow chart of patients with PsA.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalIsrael Medical Association Journal
Volume18
Issue number3-4
StatePublished - Mar 1 2016
Externally publishedYes

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Keywords

  • Biologics
  • Drug retention rate
  • Gender medicine
  • Personalized medicine
  • Psoriasis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Generali, E., Scirè, C. A., Cantarini, L., & Selmi, C. (2016). Sex differences in the treatment of Psoriatic Arthritis: A systematic literature review. Israel Medical Association Journal, 18(3-4), 203-208.