Sex differences in stress-induced social withdrawal: Independence from adult gonadal hormones and inhibition of female phenotype by corncob bedding

Brian C. Trainor, Elizabeth Y. Takahashi, Katharine L. Campi, Stefani A. Florez, Gian D. Greenberg, Abigail Laman-Maharg, Sarah A. Laredo, Veronica N. Orr, Andrea L. Silva, Michael Q. Steinman

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

There is compelling evidence for important sex differences in behavioral and hormonal responses to psychosocial stress. Here we examined the effects of gonadal hormones on behavioral responses to social defeat stress in monogamous California mice (Peromyscus californicus). Three episodes of social defeat induced social withdrawal in intact females but not males. Gonadectomy blocked corticosterone responses to defeat in females and sensitized male corticosterone responses. However, gonadectomy had no effects on social interaction behavior, suggesting that social withdrawal is not dependent on gonadal hormones in the adult California mouse. In contrast, defeat reduced exploratory behavior in the open field test for intact but not castrated males. We also examined the effects of social defeat on social interaction behavior when California mice were raised on corncob bedding, which has estrogenic properties. In this dataset of over 300 mice, we observed that social defeat did not induce social withdrawal when females were raised on corncob bedding. This finding suggests that the use of corncob in rodent studies could mask important sex differences in the effects of stress on brain and behavior. Although gonadal hormones do not affect social withdrawal behavior in adults, our data suggest that hormones may act earlier in development to induce a more resilient social phenotype.

Original languageEnglish (US)
Pages (from-to)543-550
Number of pages8
JournalHormones and Behavior
Volume63
Issue number3
DOIs
StatePublished - Mar 2013

Fingerprint

Gonadal Hormones
Sex Characteristics
Phenotype
Interpersonal Relations
Corticosterone
Peromyscus
Exploratory Behavior
Masks
Rodentia
Hormones
Inhibition (Psychology)
Brain

Keywords

  • Aggression
  • Anxiety-like behavior
  • Phytoestrogens
  • Sex differences
  • Social behavior
  • Social defeat
  • Stress

ASJC Scopus subject areas

  • Endocrinology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Trainor, B. C., Takahashi, E. Y., Campi, K. L., Florez, S. A., Greenberg, G. D., Laman-Maharg, A., ... Steinman, M. Q. (2013). Sex differences in stress-induced social withdrawal: Independence from adult gonadal hormones and inhibition of female phenotype by corncob bedding. Hormones and Behavior, 63(3), 543-550. https://doi.org/10.1016/j.yhbeh.2013.01.011

Sex differences in stress-induced social withdrawal : Independence from adult gonadal hormones and inhibition of female phenotype by corncob bedding. / Trainor, Brian C.; Takahashi, Elizabeth Y.; Campi, Katharine L.; Florez, Stefani A.; Greenberg, Gian D.; Laman-Maharg, Abigail; Laredo, Sarah A.; Orr, Veronica N.; Silva, Andrea L.; Steinman, Michael Q.

In: Hormones and Behavior, Vol. 63, No. 3, 03.2013, p. 543-550.

Research output: Contribution to journalArticle

Trainor, BC, Takahashi, EY, Campi, KL, Florez, SA, Greenberg, GD, Laman-Maharg, A, Laredo, SA, Orr, VN, Silva, AL & Steinman, MQ 2013, 'Sex differences in stress-induced social withdrawal: Independence from adult gonadal hormones and inhibition of female phenotype by corncob bedding', Hormones and Behavior, vol. 63, no. 3, pp. 543-550. https://doi.org/10.1016/j.yhbeh.2013.01.011
Trainor, Brian C. ; Takahashi, Elizabeth Y. ; Campi, Katharine L. ; Florez, Stefani A. ; Greenberg, Gian D. ; Laman-Maharg, Abigail ; Laredo, Sarah A. ; Orr, Veronica N. ; Silva, Andrea L. ; Steinman, Michael Q. / Sex differences in stress-induced social withdrawal : Independence from adult gonadal hormones and inhibition of female phenotype by corncob bedding. In: Hormones and Behavior. 2013 ; Vol. 63, No. 3. pp. 543-550.
@article{3996f52f22524641a002a5b39772f47a,
title = "Sex differences in stress-induced social withdrawal: Independence from adult gonadal hormones and inhibition of female phenotype by corncob bedding",
abstract = "There is compelling evidence for important sex differences in behavioral and hormonal responses to psychosocial stress. Here we examined the effects of gonadal hormones on behavioral responses to social defeat stress in monogamous California mice (Peromyscus californicus). Three episodes of social defeat induced social withdrawal in intact females but not males. Gonadectomy blocked corticosterone responses to defeat in females and sensitized male corticosterone responses. However, gonadectomy had no effects on social interaction behavior, suggesting that social withdrawal is not dependent on gonadal hormones in the adult California mouse. In contrast, defeat reduced exploratory behavior in the open field test for intact but not castrated males. We also examined the effects of social defeat on social interaction behavior when California mice were raised on corncob bedding, which has estrogenic properties. In this dataset of over 300 mice, we observed that social defeat did not induce social withdrawal when females were raised on corncob bedding. This finding suggests that the use of corncob in rodent studies could mask important sex differences in the effects of stress on brain and behavior. Although gonadal hormones do not affect social withdrawal behavior in adults, our data suggest that hormones may act earlier in development to induce a more resilient social phenotype.",
keywords = "Aggression, Anxiety-like behavior, Phytoestrogens, Sex differences, Social behavior, Social defeat, Stress",
author = "Trainor, {Brian C.} and Takahashi, {Elizabeth Y.} and Campi, {Katharine L.} and Florez, {Stefani A.} and Greenberg, {Gian D.} and Abigail Laman-Maharg and Laredo, {Sarah A.} and Orr, {Veronica N.} and Silva, {Andrea L.} and Steinman, {Michael Q.}",
year = "2013",
month = "3",
doi = "10.1016/j.yhbeh.2013.01.011",
language = "English (US)",
volume = "63",
pages = "543--550",
journal = "Hormones and Behavior",
issn = "0018-506X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Sex differences in stress-induced social withdrawal

T2 - Independence from adult gonadal hormones and inhibition of female phenotype by corncob bedding

AU - Trainor, Brian C.

AU - Takahashi, Elizabeth Y.

AU - Campi, Katharine L.

AU - Florez, Stefani A.

AU - Greenberg, Gian D.

AU - Laman-Maharg, Abigail

AU - Laredo, Sarah A.

AU - Orr, Veronica N.

AU - Silva, Andrea L.

AU - Steinman, Michael Q.

PY - 2013/3

Y1 - 2013/3

N2 - There is compelling evidence for important sex differences in behavioral and hormonal responses to psychosocial stress. Here we examined the effects of gonadal hormones on behavioral responses to social defeat stress in monogamous California mice (Peromyscus californicus). Three episodes of social defeat induced social withdrawal in intact females but not males. Gonadectomy blocked corticosterone responses to defeat in females and sensitized male corticosterone responses. However, gonadectomy had no effects on social interaction behavior, suggesting that social withdrawal is not dependent on gonadal hormones in the adult California mouse. In contrast, defeat reduced exploratory behavior in the open field test for intact but not castrated males. We also examined the effects of social defeat on social interaction behavior when California mice were raised on corncob bedding, which has estrogenic properties. In this dataset of over 300 mice, we observed that social defeat did not induce social withdrawal when females were raised on corncob bedding. This finding suggests that the use of corncob in rodent studies could mask important sex differences in the effects of stress on brain and behavior. Although gonadal hormones do not affect social withdrawal behavior in adults, our data suggest that hormones may act earlier in development to induce a more resilient social phenotype.

AB - There is compelling evidence for important sex differences in behavioral and hormonal responses to psychosocial stress. Here we examined the effects of gonadal hormones on behavioral responses to social defeat stress in monogamous California mice (Peromyscus californicus). Three episodes of social defeat induced social withdrawal in intact females but not males. Gonadectomy blocked corticosterone responses to defeat in females and sensitized male corticosterone responses. However, gonadectomy had no effects on social interaction behavior, suggesting that social withdrawal is not dependent on gonadal hormones in the adult California mouse. In contrast, defeat reduced exploratory behavior in the open field test for intact but not castrated males. We also examined the effects of social defeat on social interaction behavior when California mice were raised on corncob bedding, which has estrogenic properties. In this dataset of over 300 mice, we observed that social defeat did not induce social withdrawal when females were raised on corncob bedding. This finding suggests that the use of corncob in rodent studies could mask important sex differences in the effects of stress on brain and behavior. Although gonadal hormones do not affect social withdrawal behavior in adults, our data suggest that hormones may act earlier in development to induce a more resilient social phenotype.

KW - Aggression

KW - Anxiety-like behavior

KW - Phytoestrogens

KW - Sex differences

KW - Social behavior

KW - Social defeat

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=84875050800&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875050800&partnerID=8YFLogxK

U2 - 10.1016/j.yhbeh.2013.01.011

DO - 10.1016/j.yhbeh.2013.01.011

M3 - Article

C2 - 23384773

AN - SCOPUS:84875050800

VL - 63

SP - 543

EP - 550

JO - Hormones and Behavior

JF - Hormones and Behavior

SN - 0018-506X

IS - 3

ER -