Severe Vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model

Yunsook Lim, Vihas Vasu, Giuseppe Valacchi, Scott Leonard, Hnin Hnin Aung, Bettina C. Schock, Nicholas Kenyon, Chin-Shang Li, Maret Traber, Carroll E Cross

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Allergic asthma is a complex immunologically mediated disease associated with increased oxidative stress and altered antioxidant defenses. It was hypothesized that α-tocopherol (α-T) decreases oxidative stress and therefore its absence may influence allergic inflammatory process, a pathobiology known to be accompanied by oxidative stress. Therefore, selected parameters of allergic asthma sensitization and inflammation were evaluated following ovalbumin sensitization and re-challenge of α-T transfer protein (TTP) knock-out mice (TTP-/-) that have greatly reduced lung α-T levels (e.g.<5%) compared to their litter mate controls (TTP+/+). Results showed that severe α-T deficiency result in a blunted lung expression of IL-5 mRNA and IL-5 protein and plasma IgE levels compared with TTP+/+ mice following immune sensitization and rechallenge, although lung lavage eosinophil levels were comparable in both genomic strains. It is concluded that the initial stimulation of immune responses by the TTP-/- mice were generally blunted compared to the TTP+/+ mice, thus diminishing some aspects of subsequent allergic inflammatory processes.

Original languageEnglish (US)
Pages (from-to)387-396
Number of pages10
JournalFree Radical Research
Volume42
Issue number4
DOIs
StatePublished - 2008

Keywords

  • Allergic inflammation
  • Asthma
  • Cytokines
  • Eosinophils
  • IgE
  • Vitamin E

ASJC Scopus subject areas

  • Biochemistry

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