Severe Upper Airway Obstruction during Sleep

H. William Bonekat, Kimberly A Hardin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Few disorders may manifest with predominantly sleep-related obstructive breathing. Obstructive sleep apnea (OSA) is a common disorder, varies in severity and is associated with significant cardiovascular and neurocognitive morbidity. It is estimated that between 8 and 18 million people in the United States have at least mild OSA. Although the exact mechanism of OSA is not well-delineated, multiple factors contribute to the development of upper airway obstruction and include anatomic, mechanical, neurologic, and inflammatory changes in the pharynx. OSA may occur concomitantly with asthma. Approximately 74% of asthmatics experience nocturnal symptoms of airflow obstruction secondary to reactive airways disease. Similar cytokine, chemokine, and histologic changes are seen in both disorders. Sleep deprivation, chronic upper airway edema, and inflammation associated with OSA may further exacerbate nocturnal asthma symptoms. Allergic rhinitis may contribute to both OSA and asthma. Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA. Treatment with CPAP therapy has also been shown to improve both daytime and nighttime peak expiratory flow rates in patients with concomitant OSA and asthma. It is important for allergists to be aware of how OSA may complicate diagnosis and treatment of asthma and allergic rhinitis. A thorough sleep history and high clinical suspicion for OSA is indicated, particularly in asthma patients who are refractory to standard medication treatments.

Original languageEnglish (US)
Pages (from-to)191-210
Number of pages20
JournalClinical Reviews in Allergy and Immunology
Volume25
Issue number2
DOIs
StatePublished - Oct 2003

Fingerprint

Obstructive Sleep Apnea
Airway Obstruction
Sleep
Asthma
Continuous Positive Airway Pressure
Therapeutics
Peak Expiratory Flow Rate
Sleep Deprivation
Pharynx
Chemokines
Nervous System
Edema
Respiration
Cytokines
Inflammation
Morbidity

Keywords

  • Airway obstruction
  • Allergic rhinitis
  • Asthma
  • Obstructive sleep apnea

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Severe Upper Airway Obstruction during Sleep. / Bonekat, H. William; Hardin, Kimberly A.

In: Clinical Reviews in Allergy and Immunology, Vol. 25, No. 2, 10.2003, p. 191-210.

Research output: Contribution to journalArticle

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