Severe hypernatremia and transient azotemia in a cat following inadvertent intravenous administration of a commercial polyethylene glycol solution

Sabrina N. Hoehne, Casey J. Kohen, Birgit Puschner, Ingrid Gennity, Simon P. Hagley, Kate S. Farrell, Karin Unger, Laura A. Cagle, Karl Jandrey

Research output: Contribution to journalArticle

Abstract

Objective: To describe the clinical signs, clinicopathologic abnormalities, treatment, and outcome after IV administration of polyethylene glycol 3350 (PEG3350) in a cat. Case Summary: A cat was inadvertently administered 6 g/kg of PEG3350 in electrolyte solution, IV, resulting in severe hypernatremia (203 mmol/L), diffuse encephalopathy, hemolysis, and moderate azotemia. The hemolysis and acute kidney injury observed immediately following PEG3350 administration resolved with supportive care. Administration of IV and oral electrolyte-free water slowly corrected the hypernatremia and the neurologic signs subsequently improved. Complete resolution of clinical signs was documented one month following hospital discharge. The PEG3350 concentrations in serum, plasma, and urine samples confirmed toxic exposure to PEG3350. Efficacy of treatment was evident by decreasing concentrations of PEG3350 in serum after the first 24 hours of treatment. Renal elimination of PEG3350 was significant and PEG3350 was still detected in the urine 17 days after exposure. New Information Provided: This is the first report to describe the clinical signs and clinicopathologic abnormalities in a cat intoxicated with IV PEG3350. Potential pathophysiologic mechanisms are discussed, and the successful supportive medical treatment is outlined.

Original languageEnglish (US)
JournalJournal of Veterinary Emergency and Critical Care
DOIs
StateAccepted/In press - Jan 1 2019

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Hypernatremia
Azotemia
uremia
polyethylene glycol
intravenous injection
Intravenous Administration
Cats
cats
hemolysis
Hemolysis
Electrolytes
electrolytes
urine
kidneys
Urine
polyethylene glycol 3350
encephalopathy
medical treatment
Poisons
Brain Diseases

Keywords

  • feline
  • intoxication
  • polyethylene glycol
  • sodium

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Severe hypernatremia and transient azotemia in a cat following inadvertent intravenous administration of a commercial polyethylene glycol solution. / Hoehne, Sabrina N.; Kohen, Casey J.; Puschner, Birgit; Gennity, Ingrid; Hagley, Simon P.; Farrell, Kate S.; Unger, Karin; Cagle, Laura A.; Jandrey, Karl.

In: Journal of Veterinary Emergency and Critical Care, 01.01.2019.

Research output: Contribution to journalArticle

Hoehne, Sabrina N. ; Kohen, Casey J. ; Puschner, Birgit ; Gennity, Ingrid ; Hagley, Simon P. ; Farrell, Kate S. ; Unger, Karin ; Cagle, Laura A. ; Jandrey, Karl. / Severe hypernatremia and transient azotemia in a cat following inadvertent intravenous administration of a commercial polyethylene glycol solution. In: Journal of Veterinary Emergency and Critical Care. 2019.
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