Several household chemical exposures are associated with pediatric-onset multiple sclerosis

the U.S. Network of Pediatric Multiple Sclerosis Centers

Research output: Contribution to journalArticle

Abstract

Background: There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods: We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed by parents at the time of enrollment in the study. Cases included children diagnosed with MS or clinically isolated syndrome with at least two silent T2 bright lesions on MRI, recruited within 4 years of disease onset from 16 pediatric MS clinics in the USA. Multivariate analyses using logistic regression were adjusted for possible confounders including age, sex, race, ethnicity, mother's highest level of education, and urban versus rural living. Results: Questionnaire responses to household chemicals were available for 312 eligible cases (median age 15.7 years, 63% girls) and 490 healthy controls (median age 15.0, 57% girls). Exposure to rodenticides (odds ratio [OR] 2.10, 95% confidence interval [CI] 1.35–3.26, P ≤ 0.001), weed control agents (OR 1.99, 95% CI 1.36–2.92, P ≤ 0.001) and products for plant/tree disease control (OR 2.72, 95% CI 1.54–4.82, P ≤ 0.001) anytime during childhood were associated with an increased risk for pediatric-onset MS in adjusted and multiple comparisons analyses. Conclusions: Our findings suggest that exposure to specific household chemicals during early childhood is associated with the risk of developing pediatric-onset MS. Future studies are needed to elucidate a causal relationship and the exact agents involved.

Original languageEnglish (US)
JournalAnnals of Clinical and Translational Neurology
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

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Multiple Sclerosis
Pediatrics
Odds Ratio
Confidence Intervals
Rodenticides
Household Products
Weed Control
Plant Diseases
Case-Control Studies
Multivariate Analysis
Parents
Logistic Models
Mothers
Education
Surveys and Questionnaires

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Several household chemical exposures are associated with pediatric-onset multiple sclerosis. / the U.S. Network of Pediatric Multiple Sclerosis Centers.

In: Annals of Clinical and Translational Neurology, 01.01.2018.

Research output: Contribution to journalArticle

@article{dad43e53ceec41a28d14322caa5f5713,
title = "Several household chemical exposures are associated with pediatric-onset multiple sclerosis",
abstract = "Background: There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods: We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed by parents at the time of enrollment in the study. Cases included children diagnosed with MS or clinically isolated syndrome with at least two silent T2 bright lesions on MRI, recruited within 4 years of disease onset from 16 pediatric MS clinics in the USA. Multivariate analyses using logistic regression were adjusted for possible confounders including age, sex, race, ethnicity, mother's highest level of education, and urban versus rural living. Results: Questionnaire responses to household chemicals were available for 312 eligible cases (median age 15.7 years, 63{\%} girls) and 490 healthy controls (median age 15.0, 57{\%} girls). Exposure to rodenticides (odds ratio [OR] 2.10, 95{\%} confidence interval [CI] 1.35–3.26, P ≤ 0.001), weed control agents (OR 1.99, 95{\%} CI 1.36–2.92, P ≤ 0.001) and products for plant/tree disease control (OR 2.72, 95{\%} CI 1.54–4.82, P ≤ 0.001) anytime during childhood were associated with an increased risk for pediatric-onset MS in adjusted and multiple comparisons analyses. Conclusions: Our findings suggest that exposure to specific household chemicals during early childhood is associated with the risk of developing pediatric-onset MS. Future studies are needed to elucidate a causal relationship and the exact agents involved.",
author = "{the U.S. Network of Pediatric Multiple Sclerosis Centers} and Soe Mar and Shannon Liang and Michael Waltz and Casper, {T. Charles} and Manu Goyal and Benjamin Greenberg and Bianca Weinstock-Guttman and Moses Rodriguez and Gregory Aaen and Anita Belman and Barcellos, {Lisa F.} and John Rose and Mark Gorman and Leslie Benson and Meghan Candee and Tanjua Chitnis and Yolanda Harris and Ilana Kahn and Shelly Roalsted and Janace Hart and Timothy Lotze and Manikum Moodley and Jayne Ness and Mary Rensel and Jennifer Rubin and Teri Schreiner and Tillema, {Jan Mendelt} and Amy Waldman and Lauren Krupp and Graves, {Jennifer S.} and Emmanuelle Waubant",
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AU - the U.S. Network of Pediatric Multiple Sclerosis Centers

AU - Mar, Soe

AU - Liang, Shannon

AU - Waltz, Michael

AU - Casper, T. Charles

AU - Goyal, Manu

AU - Greenberg, Benjamin

AU - Weinstock-Guttman, Bianca

AU - Rodriguez, Moses

AU - Aaen, Gregory

AU - Belman, Anita

AU - Barcellos, Lisa F.

AU - Rose, John

AU - Gorman, Mark

AU - Benson, Leslie

AU - Candee, Meghan

AU - Chitnis, Tanjua

AU - Harris, Yolanda

AU - Kahn, Ilana

AU - Roalsted, Shelly

AU - Hart, Janace

AU - Lotze, Timothy

AU - Moodley, Manikum

AU - Ness, Jayne

AU - Rensel, Mary

AU - Rubin, Jennifer

AU - Schreiner, Teri

AU - Tillema, Jan Mendelt

AU - Waldman, Amy

AU - Krupp, Lauren

AU - Graves, Jennifer S.

AU - Waubant, Emmanuelle

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods: We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed by parents at the time of enrollment in the study. Cases included children diagnosed with MS or clinically isolated syndrome with at least two silent T2 bright lesions on MRI, recruited within 4 years of disease onset from 16 pediatric MS clinics in the USA. Multivariate analyses using logistic regression were adjusted for possible confounders including age, sex, race, ethnicity, mother's highest level of education, and urban versus rural living. Results: Questionnaire responses to household chemicals were available for 312 eligible cases (median age 15.7 years, 63% girls) and 490 healthy controls (median age 15.0, 57% girls). Exposure to rodenticides (odds ratio [OR] 2.10, 95% confidence interval [CI] 1.35–3.26, P ≤ 0.001), weed control agents (OR 1.99, 95% CI 1.36–2.92, P ≤ 0.001) and products for plant/tree disease control (OR 2.72, 95% CI 1.54–4.82, P ≤ 0.001) anytime during childhood were associated with an increased risk for pediatric-onset MS in adjusted and multiple comparisons analyses. Conclusions: Our findings suggest that exposure to specific household chemicals during early childhood is associated with the risk of developing pediatric-onset MS. Future studies are needed to elucidate a causal relationship and the exact agents involved.

AB - Background: There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods: We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed by parents at the time of enrollment in the study. Cases included children diagnosed with MS or clinically isolated syndrome with at least two silent T2 bright lesions on MRI, recruited within 4 years of disease onset from 16 pediatric MS clinics in the USA. Multivariate analyses using logistic regression were adjusted for possible confounders including age, sex, race, ethnicity, mother's highest level of education, and urban versus rural living. Results: Questionnaire responses to household chemicals were available for 312 eligible cases (median age 15.7 years, 63% girls) and 490 healthy controls (median age 15.0, 57% girls). Exposure to rodenticides (odds ratio [OR] 2.10, 95% confidence interval [CI] 1.35–3.26, P ≤ 0.001), weed control agents (OR 1.99, 95% CI 1.36–2.92, P ≤ 0.001) and products for plant/tree disease control (OR 2.72, 95% CI 1.54–4.82, P ≤ 0.001) anytime during childhood were associated with an increased risk for pediatric-onset MS in adjusted and multiple comparisons analyses. Conclusions: Our findings suggest that exposure to specific household chemicals during early childhood is associated with the risk of developing pediatric-onset MS. Future studies are needed to elucidate a causal relationship and the exact agents involved.

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