Abstract
A follow-up report was done of workers exposed to 1,2-dibromo-3-chloropropane (DBCP) 7 years after termination of exposure. A 1977 study of male pesticide workers exposed to DBCP in a California agricultural chemical plant identified many who were azoospermic or oligospermic. Sperm concentration and serum follicle-stimulating hormone (FSH) levels in 44 of these workers were reassessed 5 to 8 years after exposure was terminated in 1977. Two of the eight originally azoospermic workers produced sperm during the follow-up, although only one had normal sperm counts. No increase in sperm production could be detected in men who had low sperm counts in 1977, and elevated serum FSH levels did not drop in oligospermic or azoospermic men. These results suggest that permanent destruction of germinal epithelium occurs in most DBCP-sterile persons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1145-1150 |
| Number of pages | 6 |
| Journal | Journal of Occupational Medicine |
| Volume | 28 |
| Issue number | 11 |
| State | Published - 1986 |
Fingerprint
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Seven-year follow-up of workers exposed to 1,2-dibromo-3-chloropropane. / Eaton, M.; Schenker, Marc B; Whorton, D.; Samuels, S.; Perkins, C.; Overstreet, J.
In: Journal of Occupational Medicine, Vol. 28, No. 11, 1986, p. 1145-1150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Seven-year follow-up of workers exposed to 1,2-dibromo-3-chloropropane
AU - Eaton, M.
AU - Schenker, Marc B
AU - Whorton, D.
AU - Samuels, S.
AU - Perkins, C.
AU - Overstreet, J.
PY - 1986
Y1 - 1986
N2 - A follow-up report was done of workers exposed to 1,2-dibromo-3-chloropropane (DBCP) 7 years after termination of exposure. A 1977 study of male pesticide workers exposed to DBCP in a California agricultural chemical plant identified many who were azoospermic or oligospermic. Sperm concentration and serum follicle-stimulating hormone (FSH) levels in 44 of these workers were reassessed 5 to 8 years after exposure was terminated in 1977. Two of the eight originally azoospermic workers produced sperm during the follow-up, although only one had normal sperm counts. No increase in sperm production could be detected in men who had low sperm counts in 1977, and elevated serum FSH levels did not drop in oligospermic or azoospermic men. These results suggest that permanent destruction of germinal epithelium occurs in most DBCP-sterile persons.
AB - A follow-up report was done of workers exposed to 1,2-dibromo-3-chloropropane (DBCP) 7 years after termination of exposure. A 1977 study of male pesticide workers exposed to DBCP in a California agricultural chemical plant identified many who were azoospermic or oligospermic. Sperm concentration and serum follicle-stimulating hormone (FSH) levels in 44 of these workers were reassessed 5 to 8 years after exposure was terminated in 1977. Two of the eight originally azoospermic workers produced sperm during the follow-up, although only one had normal sperm counts. No increase in sperm production could be detected in men who had low sperm counts in 1977, and elevated serum FSH levels did not drop in oligospermic or azoospermic men. These results suggest that permanent destruction of germinal epithelium occurs in most DBCP-sterile persons.
UR - http://www.scopus.com/inward/record.url?scp=0023007799&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023007799&partnerID=8YFLogxK
M3 - Article
C2 - 3097279
AN - SCOPUS:0023007799
VL - 28
SP - 1145
EP - 1150
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
SN - 1076-2752
IS - 11
ER -