Seven polymorphic loci mapping to human chromosomal region 11q22-qter

Cheryl L. Maslen, Carol Jones, Thomas M Glaser, R. Ellen Magenis, Robert Sheehy, Jill Kellogg, Michael Litt

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Seven polymorphic loci that map to human chromosomal region 11q22-qter are revealed by DNA probes isolated from a chromosome-specific phage library constructed from a human × mouse somatic cell hybrid that has retained an 11q;16q translocation as the only human DNA. Three probes, each of which reveals a two-allele polymorphism, and four probes, each of which detects two linked RFLPs, have been characterized. Using a somatic cell hybrid mapping panel that divides 11q into four discrete sections, the seven clones have been localized to specific chromosomal regions. Localization of one of the clones has been confirmed and refined by in situ hybridization.

Original languageEnglish (US)
Pages (from-to)66-75
Number of pages10
JournalGenomics
Volume2
Issue number1
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Maslen, C. L., Jones, C., Glaser, T. M., Magenis, R. E., Sheehy, R., Kellogg, J., & Litt, M. (1988). Seven polymorphic loci mapping to human chromosomal region 11q22-qter. Genomics, 2(1), 66-75. https://doi.org/10.1016/0888-7543(88)90110-3