TY - JOUR
T1 - Serum stability of 67Cu chelates
T2 - Comparison with 111In and 57Co
AU - Cole, W. C.
AU - DeNardo, S. J.
AU - Meares, C. F.
PY - 1986
Y1 - 1986
N2 - Simple chelates and chelate conjugated monoclonal antibodies labeled with 111In, 57Co and 67Cu demonstrate marked differences in stability when exposed to a serum environment. Among these radiometals, on DTPA, the order of stability is 111In > 57Co ≥ 67Cu. On benzyl-EDTA, the order of stability is 111In ~ 57Co ≥ 67Cu. Among those investigated, the only serum stable 67Cu chelate found was 67Cu-TETA. The order of stability observed for 57Co vs 67Cu is contrary to published equilibrium constants. These in vitro studies suggest that the in vivo behavior of metal chelates exposed to a complex molecular environment may not be predicted by classically determined equilibrium constants.
AB - Simple chelates and chelate conjugated monoclonal antibodies labeled with 111In, 57Co and 67Cu demonstrate marked differences in stability when exposed to a serum environment. Among these radiometals, on DTPA, the order of stability is 111In > 57Co ≥ 67Cu. On benzyl-EDTA, the order of stability is 111In ~ 57Co ≥ 67Cu. Among those investigated, the only serum stable 67Cu chelate found was 67Cu-TETA. The order of stability observed for 57Co vs 67Cu is contrary to published equilibrium constants. These in vitro studies suggest that the in vivo behavior of metal chelates exposed to a complex molecular environment may not be predicted by classically determined equilibrium constants.
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M3 - Article
C2 - 3539884
AN - SCOPUS:0022485126
VL - 13
SP - 363
EP - 368
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
SN - 0969-8051
IS - 4
ER -