Abstract
Simple chelates and chelate conjugated monoclonal antibodies labeled with 111In, 57Co and 67Cu demonstrate marked differences in stability when exposed to a serum environment. Among these radiometals, on DTPA, the order of stability is 111In > 57Co ≥ 67Cu. On benzyl-EDTA, the order of stability is 111In ~ 57Co ≥ 67Cu. Among those investigated, the only serum stable 67Cu chelate found was 67Cu-TETA. The order of stability observed for 57Co vs 67Cu is contrary to published equilibrium constants. These in vitro studies suggest that the in vivo behavior of metal chelates exposed to a complex molecular environment may not be predicted by classically determined equilibrium constants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 363-368 |
| Number of pages | 6 |
| Journal | Nuclear Medicine and Biology |
| Volume | 13 |
| Issue number | 4 |
| State | Published - 1986 |
ASJC Scopus subject areas
- Cancer Research
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Medicine(all)
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Cole, W. C., DeNardo, S. J., & Meares, C. F. (1986). Serum stability of 67Cu chelates: Comparison with 111In and 57Co. Nuclear Medicine and Biology, 13(4), 363-368.