Serum stability of 67Cu chelates: Comparison with 111In and 57Co

W. C. Cole, S. J. DeNardo, C. F. Meares

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Simple chelates and chelate conjugated monoclonal antibodies labeled with 111In, 57Co and 67Cu demonstrate marked differences in stability when exposed to a serum environment. Among these radiometals, on DTPA, the order of stability is 111In > 57Co ≥ 67Cu. On benzyl-EDTA, the order of stability is 111In ~ 57Co ≥ 67Cu. Among those investigated, the only serum stable 67Cu chelate found was 67Cu-TETA. The order of stability observed for 57Co vs 67Cu is contrary to published equilibrium constants. These in vitro studies suggest that the in vivo behavior of metal chelates exposed to a complex molecular environment may not be predicted by classically determined equilibrium constants.

Original languageEnglish (US)
Pages (from-to)363-368
Number of pages6
JournalNuclear Medicine and Biology
Issue number4
StatePublished - 1986

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


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