Serum sex hormones and the 20-year risk of lower urinary tract symptoms in community-dwelling older men

Michael Trifiro, J. Kellogg Parsons, Kerrin Palazzi-Churas, Jaclyn Bergstrom, Charles Lakin, Elizabeth Barrett-Connor

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Study Type - Prognosis (inception cohort) Level of Evidence 2b Objective To evaluate serum sex steroid hormone concentrations and long-term risk of subsequent lower urinary tract symptoms (LUTS) in a cohort of community-dwelling older men. SUBJECTS AND METHODS Between 1984 and 1987, serum sex hormone concentrations were measured in participants in the Rancho Bernardo Study, a prospective, community-based study. In 2006, the American Urological Association Symptom Index (AUA-SI) was mailed to surviving male participants. Logistic regression was used to examine associations of baseline hormone concentrations with AUA-SI. Results Among 158 surviving men with complete data and no history of prostate cancer, the mean (sd) age at serum sex steroid assessment was 58 (6.6) years with a mean (sd) follow-up of 20.3 (0.6) years. In age-adjusted logistic regression, there was a significant inverse association of testosterone : dihydrotestosterone (DHT) with LUTS (P = 0.05). Also, men with higher concentrations of bioavailable testosterone had a 56% decreased risk of LUTS compared with those with hypogonadal concentrations, although the association was not statistically significant (odds ratios 0.44, 95% confidence interval 0.14-1.40) or distributed evenly among quartiles. There were no significant associations of total testosterone, oestradiol (E2), testosterone : E2, DHT, or dehydroepiandrosterone with LUTS or with any measured hormones and urinary bother. Conclusions In this cohort, men with higher mid-life levels of testosterone : DHT and bioavailable testosterone had a decreased 20-year risk of LUTS. These data support other studies reporting inverse associations of serum testosterone with LUTS. Clinical trials of testosterone therapy should include LUTS and clinical benign prostatic hyperplasia as outcomes.

Original languageEnglish (US)
Pages (from-to)1554-1559
Number of pages6
JournalBJU International
Issue number11
StatePublished - Jun 2010
Externally publishedYes


  • Benign prostatic hyperplasia
  • Hormones
  • Hypogonadism
  • Lower urinary tract symptoms
  • Testosterone

ASJC Scopus subject areas

  • Urology


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