Serum serotonin concentration in lean and obese dogs with myxomatous mitral valve disease

Kyu Tae Kim, Hee Myung Park, Changbaig Hyun, Kyoung Won Seo, Kun Ho Song

Research output: Contribution to journalArticle

Abstract

The aim of the present study is to investigate the potential influence of obesity as a factor in 5- hydroxytryptamine (5-HT) concentration in myxomatous mitral valve disease (MMVD) dogs. Fifty-five client-owned dogs were enrolled in a randomized trial. Dogs were classified by echocardiography into healthy (control), mild, and moderate to severe MMVD groups. Each group was subclassified by using a 9-point body condition score (BCS); lean (BCS 5-6/9) and obese groups (BCS 7.5-9/9). Dogs with moderate to severe MMVD had lower serotonin (5- HT) concentrations than the control group (p = 0.03). Dogs with moderate to severe MMVD (p = 0.017) had lower serum 5-HT concentrations than the control group in the obese group (BCS 7.5-9/9). Significant difference was found between the lean and obese groups (p = 0.015) which are not consider severe in the MMVD group. These results suggested that 5-HT concentration was decreased with the increasing severity of MMVD, and obesity might be taken into consideration when interpreting the serotonin concentration in MMVD dogs.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalKorean Journal of Veterinary Research
Volume56
Issue number4
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • 5-HT concentration
  • Body condition score
  • Dogs
  • Myxomatous mitral valve disease
  • Obesity

ASJC Scopus subject areas

  • veterinary(all)

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