TY - JOUR
T1 - Serum Protein Concentrations in Horses With Severe Liver Disease
T2 - A Retrospective Study and Review of the Literature
AU - Parraga, María E.
AU - Carlson, Gary P.
AU - Thurmond, Mark
PY - 1995/1/1
Y1 - 1995/1/1
N2 - The present retrospective study was undertaken to determine the frequency of hypoproteinemia and hypoalbuminemia in horses with natural occurring severe liver disease. The study represents a review of case records and laboratory data of 84 horses presented with acute or chronic liver disease to the University of California Veterinary Medical Teaching Hospital between 1973 and 1991. Forty horses (48%) had serum protein concentrations above the maximum reference value (7.7 g/dL). The increase in serum protein concentration was associated with hyperglobulinemia (P= .00005, R2= .80). Only 13% (11/84) of the horses had serum albumin concentrations below the minimum reference range (2.5 g/dL), and hypoproteinemia was found in only 1 of these horses. Of these, 18% (9/51) of the horses with chronic liver disease and 6% (2/33) of the horses with acute liver disease had albumin concentrations below the minimum reference value. Globulin concentrations in 64% of the horses (54/84) were above the maximum reference value (4.0 g/dL). The present study indicates that hypoproteinemia and hypoalbuminemia are not common features in horses with severe liver disease.
AB - The present retrospective study was undertaken to determine the frequency of hypoproteinemia and hypoalbuminemia in horses with natural occurring severe liver disease. The study represents a review of case records and laboratory data of 84 horses presented with acute or chronic liver disease to the University of California Veterinary Medical Teaching Hospital between 1973 and 1991. Forty horses (48%) had serum protein concentrations above the maximum reference value (7.7 g/dL). The increase in serum protein concentration was associated with hyperglobulinemia (P= .00005, R2= .80). Only 13% (11/84) of the horses had serum albumin concentrations below the minimum reference range (2.5 g/dL), and hypoproteinemia was found in only 1 of these horses. Of these, 18% (9/51) of the horses with chronic liver disease and 6% (2/33) of the horses with acute liver disease had albumin concentrations below the minimum reference value. Globulin concentrations in 64% of the horses (54/84) were above the maximum reference value (4.0 g/dL). The present study indicates that hypoproteinemia and hypoalbuminemia are not common features in horses with severe liver disease.
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U2 - 10.1111/j.1939-1676.1995.tb03289.x
DO - 10.1111/j.1939-1676.1995.tb03289.x
M3 - Article
C2 - 7674216
AN - SCOPUS:0029298782
VL - 9
SP - 154
EP - 161
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 3
ER -