Serum phosphate and anxiety in major depression

Richard J Maddock, James A. Moses, Walton T. Roth, Roy King, Allison Murchison, Philip A. Berger

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Serum inorganic phosphate was measured in 33 hospitalized patients with unipolar depression. As predicted, serum phosphate showed significant negative correlations with Minnesota Multiphasic Personality Inventory scales sensitive to anxiety (Psychasthenia: -0.33) and somatic concern (Hypochondriasis: -0.51). This is consistent with previous observations of relative hypophosphatemia in patients with panic disorder. Clinical consequences of relative hypophasphatemia and the possible roles of hyperventilation or elevated peripheral catecholamines as mediators of this effect are discussed.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalPsychiatry Research
Issue number1
StatePublished - 1987


  • anxiety
  • Depression
  • hyperventilation
  • phosphate

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)


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