Abstract
The aim of this study was to compare serum nitrotyrosine concentrations in healthy dogs with those in dogs with myxomatous mitral valve disease (MMVD). Fifty client-owned dogs were included in this study. Based on echocardiographic results, dogs were categorized into healthy (control), mild-, moderate-, and severe-MMVD groups. Serum nitrotyrosine concentrations were determined from enzyme-linked immunosorbent assays. No significant difference between control dogs and dogs with mild MMVD was detected (p = 0.31). However, dogs with moderate MMVD had significantly higher serum concentrations of nitrotyrosine (p = 0.04) than that in controls, and dogs with severe MMVD had significantly lower serum concentrations of nitrotyrosine (p = 0.03) than that in moderate MMVD dogs. There were negative correlations in the association of serum nitrotyrosine with age (n = 30, R2= 0.067, p = 0.27), left atrial-to-aortic root diameter ratio (n = 30, R2= 0.02, p = 0.57), and platelet count (n = 30, R2= 0.39, p = 0.003); however, only the platelet correlation was significant. Among dogs with MMVD, there was no significant difference in serum nitrotyrosine concentration between males and females. The results of this study suggest that tyrosine nitration end-products might be potential biomarkers for the detection of MMVD in dogs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 17-21 |
| Number of pages | 5 |
| Journal | Korean Journal of Veterinary Research |
| Volume | 57 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2017 |
| Externally published | Yes |
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Keywords
- Biomarker
- Canine disease
- Peroxynitrous acid
- Serum nitrotyrosine
ASJC Scopus subject areas
- veterinary(all)
Cite this
Serum nitrotyrosine concentration in dogs with myxomatous mitral valve disease. / Kim, Jun Seok; Park, Jun Seok; Park, Hyung Jin; Seo, Kyoung Won; Song, Kun Ho.
In: Korean Journal of Veterinary Research, Vol. 57, No. 1, 01.01.2017, p. 17-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum nitrotyrosine concentration in dogs with myxomatous mitral valve disease
AU - Kim, Jun Seok
AU - Park, Jun Seok
AU - Park, Hyung Jin
AU - Seo, Kyoung Won
AU - Song, Kun Ho
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The aim of this study was to compare serum nitrotyrosine concentrations in healthy dogs with those in dogs with myxomatous mitral valve disease (MMVD). Fifty client-owned dogs were included in this study. Based on echocardiographic results, dogs were categorized into healthy (control), mild-, moderate-, and severe-MMVD groups. Serum nitrotyrosine concentrations were determined from enzyme-linked immunosorbent assays. No significant difference between control dogs and dogs with mild MMVD was detected (p = 0.31). However, dogs with moderate MMVD had significantly higher serum concentrations of nitrotyrosine (p = 0.04) than that in controls, and dogs with severe MMVD had significantly lower serum concentrations of nitrotyrosine (p = 0.03) than that in moderate MMVD dogs. There were negative correlations in the association of serum nitrotyrosine with age (n = 30, R2= 0.067, p = 0.27), left atrial-to-aortic root diameter ratio (n = 30, R2= 0.02, p = 0.57), and platelet count (n = 30, R2= 0.39, p = 0.003); however, only the platelet correlation was significant. Among dogs with MMVD, there was no significant difference in serum nitrotyrosine concentration between males and females. The results of this study suggest that tyrosine nitration end-products might be potential biomarkers for the detection of MMVD in dogs.
AB - The aim of this study was to compare serum nitrotyrosine concentrations in healthy dogs with those in dogs with myxomatous mitral valve disease (MMVD). Fifty client-owned dogs were included in this study. Based on echocardiographic results, dogs were categorized into healthy (control), mild-, moderate-, and severe-MMVD groups. Serum nitrotyrosine concentrations were determined from enzyme-linked immunosorbent assays. No significant difference between control dogs and dogs with mild MMVD was detected (p = 0.31). However, dogs with moderate MMVD had significantly higher serum concentrations of nitrotyrosine (p = 0.04) than that in controls, and dogs with severe MMVD had significantly lower serum concentrations of nitrotyrosine (p = 0.03) than that in moderate MMVD dogs. There were negative correlations in the association of serum nitrotyrosine with age (n = 30, R2= 0.067, p = 0.27), left atrial-to-aortic root diameter ratio (n = 30, R2= 0.02, p = 0.57), and platelet count (n = 30, R2= 0.39, p = 0.003); however, only the platelet correlation was significant. Among dogs with MMVD, there was no significant difference in serum nitrotyrosine concentration between males and females. The results of this study suggest that tyrosine nitration end-products might be potential biomarkers for the detection of MMVD in dogs.
KW - Biomarker
KW - Canine disease
KW - Peroxynitrous acid
KW - Serum nitrotyrosine
UR - http://www.scopus.com/inward/record.url?scp=85016570407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016570407&partnerID=8YFLogxK
U2 - 10.14405/kjvr.2017.57.1.17
DO - 10.14405/kjvr.2017.57.1.17
M3 - Article
AN - SCOPUS:85016570407
VL - 57
SP - 17
EP - 21
JO - Korean Journal of Veterinary Research
JF - Korean Journal of Veterinary Research
SN - 1225-0198
IS - 1
ER -