Serum leptin in nonpregnant and pregnant women and in old and new world nonhuman primates

V. Daniel Castracane, Andrew G Hendrickx, Michael C. Henson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Leptin is a hormone that is produced during mammalian pregnancy in the placental trophoblast and other tissues, including! fetal and maternal adipocytes. Synthesis of the polypeptide and the presence of its specific receptors throughout the human maternal fetoplacental unit suggest direct effects on conceptus growth and development. However, both the physiologic roles of leptin and the mechanisms regulating leptin synthesis in human pregnancy differ from those in laboratory and domestic species, necessitating the development of non-human primate research models. Therefore, we compared serum leptin concentrations in nonpregnant and pregnant women with those in both old world nonhuman primates (i.e., baboon, rhesus monkey, cynomolgus monkey) and new world nonhuman primates (i.e., squirrel monkey, titi monkey). As expected, maternal leptin levels were elevated in human and baboon pregnancies (P < 0.05 and P < 0.001, respectively). Levels in both species of old world monkeys were also greatly enhanced (P < 0.001). Although maternal serum concentrations were slightly elevated compared to nonpregnant levels in both species of new world monkeys, overall concentrations were dramatically lower than for either old world primates or humans. Results provide comparisons of serum leptin concentrations in pregnant and nonpregnant humans and baboons with those in both old and new world monkeys and further characterize these nonhuman primates as models for the investigation of leptin dynamics in pregnancy.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalExperimental Biology and Medicine
Volume230
Issue number4
StatePublished - Apr 2005

Fingerprint

Leptin
Primates
Pregnant Women
Serum
Papio
Mothers
Platyrrhini
Cercopithecidae
Pregnancy
Saimiri
Macaca fascicularis
Trophoblasts
Human Development
Macaca mulatta
Growth and Development
Adipocytes
Haplorhini
Hormones
Tissue
Peptides

Keywords

  • Leptin
  • New world primates
  • Old world primates
  • Pregnancy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Castracane, V. D., Hendrickx, A. G., & Henson, M. C. (2005). Serum leptin in nonpregnant and pregnant women and in old and new world nonhuman primates. Experimental Biology and Medicine, 230(4), 251-254.

Serum leptin in nonpregnant and pregnant women and in old and new world nonhuman primates. / Castracane, V. Daniel; Hendrickx, Andrew G; Henson, Michael C.

In: Experimental Biology and Medicine, Vol. 230, No. 4, 04.2005, p. 251-254.

Research output: Contribution to journalArticle

Castracane, VD, Hendrickx, AG & Henson, MC 2005, 'Serum leptin in nonpregnant and pregnant women and in old and new world nonhuman primates', Experimental Biology and Medicine, vol. 230, no. 4, pp. 251-254.
Castracane, V. Daniel ; Hendrickx, Andrew G ; Henson, Michael C. / Serum leptin in nonpregnant and pregnant women and in old and new world nonhuman primates. In: Experimental Biology and Medicine. 2005 ; Vol. 230, No. 4. pp. 251-254.
@article{2c1b153df654469d8a22e99032b45244,
title = "Serum leptin in nonpregnant and pregnant women and in old and new world nonhuman primates",
abstract = "Leptin is a hormone that is produced during mammalian pregnancy in the placental trophoblast and other tissues, including! fetal and maternal adipocytes. Synthesis of the polypeptide and the presence of its specific receptors throughout the human maternal fetoplacental unit suggest direct effects on conceptus growth and development. However, both the physiologic roles of leptin and the mechanisms regulating leptin synthesis in human pregnancy differ from those in laboratory and domestic species, necessitating the development of non-human primate research models. Therefore, we compared serum leptin concentrations in nonpregnant and pregnant women with those in both old world nonhuman primates (i.e., baboon, rhesus monkey, cynomolgus monkey) and new world nonhuman primates (i.e., squirrel monkey, titi monkey). As expected, maternal leptin levels were elevated in human and baboon pregnancies (P < 0.05 and P < 0.001, respectively). Levels in both species of old world monkeys were also greatly enhanced (P < 0.001). Although maternal serum concentrations were slightly elevated compared to nonpregnant levels in both species of new world monkeys, overall concentrations were dramatically lower than for either old world primates or humans. Results provide comparisons of serum leptin concentrations in pregnant and nonpregnant humans and baboons with those in both old and new world monkeys and further characterize these nonhuman primates as models for the investigation of leptin dynamics in pregnancy.",
keywords = "Leptin, New world primates, Old world primates, Pregnancy",
author = "Castracane, {V. Daniel} and Hendrickx, {Andrew G} and Henson, {Michael C.}",
year = "2005",
month = "4",
language = "English (US)",
volume = "230",
pages = "251--254",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "1535-3702",
publisher = "Society for Experimental Biology and Medicine",
number = "4",

}

TY - JOUR

T1 - Serum leptin in nonpregnant and pregnant women and in old and new world nonhuman primates

AU - Castracane, V. Daniel

AU - Hendrickx, Andrew G

AU - Henson, Michael C.

PY - 2005/4

Y1 - 2005/4

N2 - Leptin is a hormone that is produced during mammalian pregnancy in the placental trophoblast and other tissues, including! fetal and maternal adipocytes. Synthesis of the polypeptide and the presence of its specific receptors throughout the human maternal fetoplacental unit suggest direct effects on conceptus growth and development. However, both the physiologic roles of leptin and the mechanisms regulating leptin synthesis in human pregnancy differ from those in laboratory and domestic species, necessitating the development of non-human primate research models. Therefore, we compared serum leptin concentrations in nonpregnant and pregnant women with those in both old world nonhuman primates (i.e., baboon, rhesus monkey, cynomolgus monkey) and new world nonhuman primates (i.e., squirrel monkey, titi monkey). As expected, maternal leptin levels were elevated in human and baboon pregnancies (P < 0.05 and P < 0.001, respectively). Levels in both species of old world monkeys were also greatly enhanced (P < 0.001). Although maternal serum concentrations were slightly elevated compared to nonpregnant levels in both species of new world monkeys, overall concentrations were dramatically lower than for either old world primates or humans. Results provide comparisons of serum leptin concentrations in pregnant and nonpregnant humans and baboons with those in both old and new world monkeys and further characterize these nonhuman primates as models for the investigation of leptin dynamics in pregnancy.

AB - Leptin is a hormone that is produced during mammalian pregnancy in the placental trophoblast and other tissues, including! fetal and maternal adipocytes. Synthesis of the polypeptide and the presence of its specific receptors throughout the human maternal fetoplacental unit suggest direct effects on conceptus growth and development. However, both the physiologic roles of leptin and the mechanisms regulating leptin synthesis in human pregnancy differ from those in laboratory and domestic species, necessitating the development of non-human primate research models. Therefore, we compared serum leptin concentrations in nonpregnant and pregnant women with those in both old world nonhuman primates (i.e., baboon, rhesus monkey, cynomolgus monkey) and new world nonhuman primates (i.e., squirrel monkey, titi monkey). As expected, maternal leptin levels were elevated in human and baboon pregnancies (P < 0.05 and P < 0.001, respectively). Levels in both species of old world monkeys were also greatly enhanced (P < 0.001). Although maternal serum concentrations were slightly elevated compared to nonpregnant levels in both species of new world monkeys, overall concentrations were dramatically lower than for either old world primates or humans. Results provide comparisons of serum leptin concentrations in pregnant and nonpregnant humans and baboons with those in both old and new world monkeys and further characterize these nonhuman primates as models for the investigation of leptin dynamics in pregnancy.

KW - Leptin

KW - New world primates

KW - Old world primates

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=16444385230&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16444385230&partnerID=8YFLogxK

M3 - Article

C2 - 15792946

AN - SCOPUS:16444385230

VL - 230

SP - 251

EP - 254

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 1535-3702

IS - 4

ER -