Serum is chemotactic for retinal-derived glial cells

E. De Juan, J. S. Dickson, Leonard M Hjelmeland

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Retinal glial cells participate in nearly all proliferative retinopathies. Little is known about factors that can stimulate these cells to migrate from the retina and proliferate. We cultured retinal glial cells from immature rats and observed the migratory and proliferative responses to serum (0% to 10%) and two of its components, platelet-derived growth factor (PDGF) (0 to 30 ng/mL) and fibronectin (0 to 20 mg/L). We found that 1% serum causes a fivefold increase in migration of the retinal glia and a 170% increase in proliferation over baseline. Fibronectin caused a threefold increase in migration at 30 mg/L, and PDGF caused a fourfold increase at 20 ng/mL, but only PDGF caused an increase in proliferation (300% at 10 ng/mL).

Original languageEnglish (US)
Pages (from-to)986-990
Number of pages5
JournalArchives of Ophthalmology
Volume106
Issue number7
StatePublished - 1988
Externally publishedYes

Fingerprint

Platelet-Derived Growth Factor
Neuroglia
Fibronectins
Serum
Retina

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Serum is chemotactic for retinal-derived glial cells. / De Juan, E.; Dickson, J. S.; Hjelmeland, Leonard M.

In: Archives of Ophthalmology, Vol. 106, No. 7, 1988, p. 986-990.

Research output: Contribution to journalArticle

De Juan, E, Dickson, JS & Hjelmeland, LM 1988, 'Serum is chemotactic for retinal-derived glial cells', Archives of Ophthalmology, vol. 106, no. 7, pp. 986-990.
De Juan, E. ; Dickson, J. S. ; Hjelmeland, Leonard M. / Serum is chemotactic for retinal-derived glial cells. In: Archives of Ophthalmology. 1988 ; Vol. 106, No. 7. pp. 986-990.
@article{4e39041fcccf4259a1a90dd0e55152c5,
title = "Serum is chemotactic for retinal-derived glial cells",
abstract = "Retinal glial cells participate in nearly all proliferative retinopathies. Little is known about factors that can stimulate these cells to migrate from the retina and proliferate. We cultured retinal glial cells from immature rats and observed the migratory and proliferative responses to serum (0{\%} to 10{\%}) and two of its components, platelet-derived growth factor (PDGF) (0 to 30 ng/mL) and fibronectin (0 to 20 mg/L). We found that 1{\%} serum causes a fivefold increase in migration of the retinal glia and a 170{\%} increase in proliferation over baseline. Fibronectin caused a threefold increase in migration at 30 mg/L, and PDGF caused a fourfold increase at 20 ng/mL, but only PDGF caused an increase in proliferation (300{\%} at 10 ng/mL).",
author = "{De Juan}, E. and Dickson, {J. S.} and Hjelmeland, {Leonard M}",
year = "1988",
language = "English (US)",
volume = "106",
pages = "986--990",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "7",

}

TY - JOUR

T1 - Serum is chemotactic for retinal-derived glial cells

AU - De Juan, E.

AU - Dickson, J. S.

AU - Hjelmeland, Leonard M

PY - 1988

Y1 - 1988

N2 - Retinal glial cells participate in nearly all proliferative retinopathies. Little is known about factors that can stimulate these cells to migrate from the retina and proliferate. We cultured retinal glial cells from immature rats and observed the migratory and proliferative responses to serum (0% to 10%) and two of its components, platelet-derived growth factor (PDGF) (0 to 30 ng/mL) and fibronectin (0 to 20 mg/L). We found that 1% serum causes a fivefold increase in migration of the retinal glia and a 170% increase in proliferation over baseline. Fibronectin caused a threefold increase in migration at 30 mg/L, and PDGF caused a fourfold increase at 20 ng/mL, but only PDGF caused an increase in proliferation (300% at 10 ng/mL).

AB - Retinal glial cells participate in nearly all proliferative retinopathies. Little is known about factors that can stimulate these cells to migrate from the retina and proliferate. We cultured retinal glial cells from immature rats and observed the migratory and proliferative responses to serum (0% to 10%) and two of its components, platelet-derived growth factor (PDGF) (0 to 30 ng/mL) and fibronectin (0 to 20 mg/L). We found that 1% serum causes a fivefold increase in migration of the retinal glia and a 170% increase in proliferation over baseline. Fibronectin caused a threefold increase in migration at 30 mg/L, and PDGF caused a fourfold increase at 20 ng/mL, but only PDGF caused an increase in proliferation (300% at 10 ng/mL).

UR - http://www.scopus.com/inward/record.url?scp=0023677269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023677269&partnerID=8YFLogxK

M3 - Article

VL - 106

SP - 986

EP - 990

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 7

ER -