Abstract
Background: Serum insulin-like growth factor-I (IGF-I) has been used in place of serum growth hormone quantification for identifying acromegaly in diabetic cats. The utility of IGF-I as a screening test for acromegaly has not been critically evaluated. This retrospective study was performed to evaluate the usefulness of serum IGF-I concentration for identifying acromegaly. Hypothesis: Serum IGF-I is a useful screening test for acromegaly in diabetic cats. Animals: A review was made of the medical records of 74 diabetic cats that had serum IGF-I quantified. The diabetes was classified as well controlled (15 cats), poorly controlled because of problems with the insulin treatment regimen, concurrent disease, or both (40), or poorly controlled with clinical findings consistent with acromegaly (19). Methods: A review of medical records was made. Results: Serum IGF-I concentration was significantly (P < .0001) increased in acromegalic diabetic cats, compared with well-controlled and poorly controlled diabetic cats. Sensitivity and specificity for serum IGF-I concentration were 84% (95% confidence interval [CI] = 60.4-96.6%) and 92% (95% CI = 81.3-97.2%), respectively. There was no significant correlation between serum IGF-I concentration and duration of insulin treatment (r = 0.23, P = .089), insulin dosage (r = 0.14, P = .30), age (r = 0.16, P = .12), and pituitary volume (r = 0.40, P = .11), but a modest correlation was found between serum IGF-I concentration and body weight (r = 0.48, P < .0001). Conclusions and Clinical Importance: Results support the use of serum IGF-I concentration as a screening test for acromegaly in diabetic cats that have clinical findings supportive of the disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 892-898 |
| Number of pages | 7 |
| Journal | Journal of Veterinary Internal Medicine |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2007 |
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Keywords
- Cat
- Glucose homeostasis
- Growth hormone
- Insulin resistance
- Pituitary tumor
ASJC Scopus subject areas
- veterinary(all)
Cite this
Serum insulin-like growth factor-I concentration in cats with diabetes mellitus and acromegaly. / Berg, Rebecca I M; Nelson, Richard W; Feldman, Edward C; Kass, Philip H; Pollard, Rachel E; Refsal, Kent R.
In: Journal of Veterinary Internal Medicine, Vol. 21, No. 5, 09.2007, p. 892-898.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum insulin-like growth factor-I concentration in cats with diabetes mellitus and acromegaly
AU - Berg, Rebecca I M
AU - Nelson, Richard W
AU - Feldman, Edward C
AU - Kass, Philip H
AU - Pollard, Rachel E
AU - Refsal, Kent R.
PY - 2007/9
Y1 - 2007/9
N2 - Background: Serum insulin-like growth factor-I (IGF-I) has been used in place of serum growth hormone quantification for identifying acromegaly in diabetic cats. The utility of IGF-I as a screening test for acromegaly has not been critically evaluated. This retrospective study was performed to evaluate the usefulness of serum IGF-I concentration for identifying acromegaly. Hypothesis: Serum IGF-I is a useful screening test for acromegaly in diabetic cats. Animals: A review was made of the medical records of 74 diabetic cats that had serum IGF-I quantified. The diabetes was classified as well controlled (15 cats), poorly controlled because of problems with the insulin treatment regimen, concurrent disease, or both (40), or poorly controlled with clinical findings consistent with acromegaly (19). Methods: A review of medical records was made. Results: Serum IGF-I concentration was significantly (P < .0001) increased in acromegalic diabetic cats, compared with well-controlled and poorly controlled diabetic cats. Sensitivity and specificity for serum IGF-I concentration were 84% (95% confidence interval [CI] = 60.4-96.6%) and 92% (95% CI = 81.3-97.2%), respectively. There was no significant correlation between serum IGF-I concentration and duration of insulin treatment (r = 0.23, P = .089), insulin dosage (r = 0.14, P = .30), age (r = 0.16, P = .12), and pituitary volume (r = 0.40, P = .11), but a modest correlation was found between serum IGF-I concentration and body weight (r = 0.48, P < .0001). Conclusions and Clinical Importance: Results support the use of serum IGF-I concentration as a screening test for acromegaly in diabetic cats that have clinical findings supportive of the disease.
AB - Background: Serum insulin-like growth factor-I (IGF-I) has been used in place of serum growth hormone quantification for identifying acromegaly in diabetic cats. The utility of IGF-I as a screening test for acromegaly has not been critically evaluated. This retrospective study was performed to evaluate the usefulness of serum IGF-I concentration for identifying acromegaly. Hypothesis: Serum IGF-I is a useful screening test for acromegaly in diabetic cats. Animals: A review was made of the medical records of 74 diabetic cats that had serum IGF-I quantified. The diabetes was classified as well controlled (15 cats), poorly controlled because of problems with the insulin treatment regimen, concurrent disease, or both (40), or poorly controlled with clinical findings consistent with acromegaly (19). Methods: A review of medical records was made. Results: Serum IGF-I concentration was significantly (P < .0001) increased in acromegalic diabetic cats, compared with well-controlled and poorly controlled diabetic cats. Sensitivity and specificity for serum IGF-I concentration were 84% (95% confidence interval [CI] = 60.4-96.6%) and 92% (95% CI = 81.3-97.2%), respectively. There was no significant correlation between serum IGF-I concentration and duration of insulin treatment (r = 0.23, P = .089), insulin dosage (r = 0.14, P = .30), age (r = 0.16, P = .12), and pituitary volume (r = 0.40, P = .11), but a modest correlation was found between serum IGF-I concentration and body weight (r = 0.48, P < .0001). Conclusions and Clinical Importance: Results support the use of serum IGF-I concentration as a screening test for acromegaly in diabetic cats that have clinical findings supportive of the disease.
KW - Cat
KW - Glucose homeostasis
KW - Growth hormone
KW - Insulin resistance
KW - Pituitary tumor
UR - http://www.scopus.com/inward/record.url?scp=34848832639&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34848832639&partnerID=8YFLogxK
U2 - 10.1892/0891-6640(2007)21[892:SIGFCI]2.0.CO;2
DO - 10.1892/0891-6640(2007)21[892:SIGFCI]2.0.CO;2
M3 - Article
C2 - 17939540
AN - SCOPUS:34848832639
VL - 21
SP - 892
EP - 898
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 5
ER -