Serum ferritin and transferrin receptor concentrations during the transition from adolescence to adulthood in a healthy Swedish population

G. Samuelson, B. Lönnerdal, B. Kempe, J. E. Elverby, L. E. Bratteby

Research output: Contribution to journalArticle

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Abstract

Aim: As part of a longitudinal nutrition study of adolescents, changes in serum ferritin (s-Ft), serum transferrin receptors (s-TfR) and the TfR/Ft ratio from 15 to 21 y of age were studied in randomly selected Swedish adolescents. Methods: Blood samples from 60 males and 66 females were drawn at 15, 17 and 21 y of age. Results: In males, median s-Ft increased significantly from 33 μg 1-1 at 15 y to 96 μg 1-1 at 21 y, and in females, after a non-significant decrease at 17 y, from 27 at 15 y to 34 μg 1-1 at 21 y. Between 15 and 17 y, s-TfR increased significantly, in males from 5.9 to 7.7 μg 1-1, and in females from 5.2 to 7.6 μg 1-1, whereas s-TfR decreased significantly in both genders between 17 and 21 y. The log (TfR/Ft) ratio did not change in males between 15 and 17 y, but decreased significantly from 2.2 ± 0.3 to 1.8 ± 0.3 by the age of 21 y. In females, the TfR/Ft ratio increased significantly between 15 and 17 y, whereas a significant decrease was found by the age of 21 y. S-Ft <12 μg 1-1 at 15, 17 and 21 y was 3, 2 and 2% in males, and in females 18, 26 and 21%, respectively. Conclusion: This study shows an increase in s-Ft and a decline in s-TfR in males, indicating increased iron stores. In females, s-Ft did not increase significantly, whereas s-TfR and the TfR/Ft ratio decreased between 17 and 21 y, indicating that cellular iron needs were met.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics
Volume92
Issue number1
StatePublished - 2003

Fingerprint

Transferrin Receptors
Serum
Ferritins
Population
Iron
ferritin receptor
Longitudinal Studies

Keywords

  • Adolescents
  • Serum ferritin
  • Serum transferrin receptor
  • Transferrin receptor/ferritin ratio

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Serum ferritin and transferrin receptor concentrations during the transition from adolescence to adulthood in a healthy Swedish population. / Samuelson, G.; Lönnerdal, B.; Kempe, B.; Elverby, J. E.; Bratteby, L. E.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 92, No. 1, 2003, p. 5-11.

Research output: Contribution to journalArticle

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title = "Serum ferritin and transferrin receptor concentrations during the transition from adolescence to adulthood in a healthy Swedish population",
abstract = "Aim: As part of a longitudinal nutrition study of adolescents, changes in serum ferritin (s-Ft), serum transferrin receptors (s-TfR) and the TfR/Ft ratio from 15 to 21 y of age were studied in randomly selected Swedish adolescents. Methods: Blood samples from 60 males and 66 females were drawn at 15, 17 and 21 y of age. Results: In males, median s-Ft increased significantly from 33 μg 1-1 at 15 y to 96 μg 1-1 at 21 y, and in females, after a non-significant decrease at 17 y, from 27 at 15 y to 34 μg 1-1 at 21 y. Between 15 and 17 y, s-TfR increased significantly, in males from 5.9 to 7.7 μg 1-1, and in females from 5.2 to 7.6 μg 1-1, whereas s-TfR decreased significantly in both genders between 17 and 21 y. The log (TfR/Ft) ratio did not change in males between 15 and 17 y, but decreased significantly from 2.2 ± 0.3 to 1.8 ± 0.3 by the age of 21 y. In females, the TfR/Ft ratio increased significantly between 15 and 17 y, whereas a significant decrease was found by the age of 21 y. S-Ft <12 μg 1-1 at 15, 17 and 21 y was 3, 2 and 2{\%} in males, and in females 18, 26 and 21{\%}, respectively. Conclusion: This study shows an increase in s-Ft and a decline in s-TfR in males, indicating increased iron stores. In females, s-Ft did not increase significantly, whereas s-TfR and the TfR/Ft ratio decreased between 17 and 21 y, indicating that cellular iron needs were met.",
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T1 - Serum ferritin and transferrin receptor concentrations during the transition from adolescence to adulthood in a healthy Swedish population

AU - Samuelson, G.

AU - Lönnerdal, B.

AU - Kempe, B.

AU - Elverby, J. E.

AU - Bratteby, L. E.

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N2 - Aim: As part of a longitudinal nutrition study of adolescents, changes in serum ferritin (s-Ft), serum transferrin receptors (s-TfR) and the TfR/Ft ratio from 15 to 21 y of age were studied in randomly selected Swedish adolescents. Methods: Blood samples from 60 males and 66 females were drawn at 15, 17 and 21 y of age. Results: In males, median s-Ft increased significantly from 33 μg 1-1 at 15 y to 96 μg 1-1 at 21 y, and in females, after a non-significant decrease at 17 y, from 27 at 15 y to 34 μg 1-1 at 21 y. Between 15 and 17 y, s-TfR increased significantly, in males from 5.9 to 7.7 μg 1-1, and in females from 5.2 to 7.6 μg 1-1, whereas s-TfR decreased significantly in both genders between 17 and 21 y. The log (TfR/Ft) ratio did not change in males between 15 and 17 y, but decreased significantly from 2.2 ± 0.3 to 1.8 ± 0.3 by the age of 21 y. In females, the TfR/Ft ratio increased significantly between 15 and 17 y, whereas a significant decrease was found by the age of 21 y. S-Ft <12 μg 1-1 at 15, 17 and 21 y was 3, 2 and 2% in males, and in females 18, 26 and 21%, respectively. Conclusion: This study shows an increase in s-Ft and a decline in s-TfR in males, indicating increased iron stores. In females, s-Ft did not increase significantly, whereas s-TfR and the TfR/Ft ratio decreased between 17 and 21 y, indicating that cellular iron needs were met.

AB - Aim: As part of a longitudinal nutrition study of adolescents, changes in serum ferritin (s-Ft), serum transferrin receptors (s-TfR) and the TfR/Ft ratio from 15 to 21 y of age were studied in randomly selected Swedish adolescents. Methods: Blood samples from 60 males and 66 females were drawn at 15, 17 and 21 y of age. Results: In males, median s-Ft increased significantly from 33 μg 1-1 at 15 y to 96 μg 1-1 at 21 y, and in females, after a non-significant decrease at 17 y, from 27 at 15 y to 34 μg 1-1 at 21 y. Between 15 and 17 y, s-TfR increased significantly, in males from 5.9 to 7.7 μg 1-1, and in females from 5.2 to 7.6 μg 1-1, whereas s-TfR decreased significantly in both genders between 17 and 21 y. The log (TfR/Ft) ratio did not change in males between 15 and 17 y, but decreased significantly from 2.2 ± 0.3 to 1.8 ± 0.3 by the age of 21 y. In females, the TfR/Ft ratio increased significantly between 15 and 17 y, whereas a significant decrease was found by the age of 21 y. S-Ft <12 μg 1-1 at 15, 17 and 21 y was 3, 2 and 2% in males, and in females 18, 26 and 21%, respectively. Conclusion: This study shows an increase in s-Ft and a decline in s-TfR in males, indicating increased iron stores. In females, s-Ft did not increase significantly, whereas s-TfR and the TfR/Ft ratio decreased between 17 and 21 y, indicating that cellular iron needs were met.

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