Abstract
Aim: As part of a longitudinal nutrition study of adolescents, changes in serum ferritin (s-Ft), serum transferrin receptors (s-TfR) and the TfR/Ft ratio from 15 to 21 y of age were studied in randomly selected Swedish adolescents. Methods: Blood samples from 60 males and 66 females were drawn at 15, 17 and 21 y of age. Results: In males, median s-Ft increased significantly from 33 μg 1-1 at 15 y to 96 μg 1-1 at 21 y, and in females, after a non-significant decrease at 17 y, from 27 at 15 y to 34 μg 1-1 at 21 y. Between 15 and 17 y, s-TfR increased significantly, in males from 5.9 to 7.7 μg 1-1, and in females from 5.2 to 7.6 μg 1-1, whereas s-TfR decreased significantly in both genders between 17 and 21 y. The log (TfR/Ft) ratio did not change in males between 15 and 17 y, but decreased significantly from 2.2 ± 0.3 to 1.8 ± 0.3 by the age of 21 y. In females, the TfR/Ft ratio increased significantly between 15 and 17 y, whereas a significant decrease was found by the age of 21 y. S-Ft <12 μg 1-1 at 15, 17 and 21 y was 3, 2 and 2% in males, and in females 18, 26 and 21%, respectively. Conclusion: This study shows an increase in s-Ft and a decline in s-TfR in males, indicating increased iron stores. In females, s-Ft did not increase significantly, whereas s-TfR and the TfR/Ft ratio decreased between 17 and 21 y, indicating that cellular iron needs were met.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5-11 |
| Number of pages | 7 |
| Journal | Acta Paediatrica, International Journal of Paediatrics |
| Volume | 92 |
| Issue number | 1 |
| State | Published - 2003 |
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Keywords
- Adolescents
- Serum ferritin
- Serum transferrin receptor
- Transferrin receptor/ferritin ratio
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Serum ferritin and transferrin receptor concentrations during the transition from adolescence to adulthood in a healthy Swedish population. / Samuelson, G.; Lönnerdal, B.; Kempe, B.; Elverby, J. E.; Bratteby, L. E.
In: Acta Paediatrica, International Journal of Paediatrics, Vol. 92, No. 1, 2003, p. 5-11.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum ferritin and transferrin receptor concentrations during the transition from adolescence to adulthood in a healthy Swedish population
AU - Samuelson, G.
AU - Lönnerdal, B.
AU - Kempe, B.
AU - Elverby, J. E.
AU - Bratteby, L. E.
PY - 2003
Y1 - 2003
N2 - Aim: As part of a longitudinal nutrition study of adolescents, changes in serum ferritin (s-Ft), serum transferrin receptors (s-TfR) and the TfR/Ft ratio from 15 to 21 y of age were studied in randomly selected Swedish adolescents. Methods: Blood samples from 60 males and 66 females were drawn at 15, 17 and 21 y of age. Results: In males, median s-Ft increased significantly from 33 μg 1-1 at 15 y to 96 μg 1-1 at 21 y, and in females, after a non-significant decrease at 17 y, from 27 at 15 y to 34 μg 1-1 at 21 y. Between 15 and 17 y, s-TfR increased significantly, in males from 5.9 to 7.7 μg 1-1, and in females from 5.2 to 7.6 μg 1-1, whereas s-TfR decreased significantly in both genders between 17 and 21 y. The log (TfR/Ft) ratio did not change in males between 15 and 17 y, but decreased significantly from 2.2 ± 0.3 to 1.8 ± 0.3 by the age of 21 y. In females, the TfR/Ft ratio increased significantly between 15 and 17 y, whereas a significant decrease was found by the age of 21 y. S-Ft <12 μg 1-1 at 15, 17 and 21 y was 3, 2 and 2% in males, and in females 18, 26 and 21%, respectively. Conclusion: This study shows an increase in s-Ft and a decline in s-TfR in males, indicating increased iron stores. In females, s-Ft did not increase significantly, whereas s-TfR and the TfR/Ft ratio decreased between 17 and 21 y, indicating that cellular iron needs were met.
AB - Aim: As part of a longitudinal nutrition study of adolescents, changes in serum ferritin (s-Ft), serum transferrin receptors (s-TfR) and the TfR/Ft ratio from 15 to 21 y of age were studied in randomly selected Swedish adolescents. Methods: Blood samples from 60 males and 66 females were drawn at 15, 17 and 21 y of age. Results: In males, median s-Ft increased significantly from 33 μg 1-1 at 15 y to 96 μg 1-1 at 21 y, and in females, after a non-significant decrease at 17 y, from 27 at 15 y to 34 μg 1-1 at 21 y. Between 15 and 17 y, s-TfR increased significantly, in males from 5.9 to 7.7 μg 1-1, and in females from 5.2 to 7.6 μg 1-1, whereas s-TfR decreased significantly in both genders between 17 and 21 y. The log (TfR/Ft) ratio did not change in males between 15 and 17 y, but decreased significantly from 2.2 ± 0.3 to 1.8 ± 0.3 by the age of 21 y. In females, the TfR/Ft ratio increased significantly between 15 and 17 y, whereas a significant decrease was found by the age of 21 y. S-Ft <12 μg 1-1 at 15, 17 and 21 y was 3, 2 and 2% in males, and in females 18, 26 and 21%, respectively. Conclusion: This study shows an increase in s-Ft and a decline in s-TfR in males, indicating increased iron stores. In females, s-Ft did not increase significantly, whereas s-TfR and the TfR/Ft ratio decreased between 17 and 21 y, indicating that cellular iron needs were met.
KW - Adolescents
KW - Serum ferritin
KW - Serum transferrin receptor
KW - Transferrin receptor/ferritin ratio
UR - http://www.scopus.com/inward/record.url?scp=0346666941&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0346666941&partnerID=8YFLogxK
M3 - Article
C2 - 12650291
AN - SCOPUS:0346666941
VL - 92
SP - 5
EP - 11
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
SN - 0803-5253
IS - 1
ER -