Abstract
Fatty acid binding protein (FABP) 4 chaperones free fatty acids (FFAs) in the adipocytes during lipolysis. Serum FFA relates to metabolic syndrome, and serum FABP4 is emerging as a novel risk marker. In 36 overweight/obese women, serum FABP4 and FFA were measured hourly during 5-hour oral glucose tolerance test. Insulin resistance was determined using frequently sampled intravenous glucose tolerance test. Serum lipids and inflammation markers were measured at fasting. During oral glucose tolerance test, serum FABP4 decreased by 40%, reaching its nadir at 3 hours (from 45.3 ± 3.1 to 31.9 ± 1.6 ng/mL), and stayed below the baseline at 5 hours (35.9 ± 2.2 ng/mL) (P < .0001 for both, compared with the baseline). Serum FFA decreased by 10-fold, reaching a nadir at 2 hours (from 0.611 ± 0.033 to 0.067 ± 0.004 mmol/L), then rebounded to 0.816 ± 0.035 mmol/L at 5 hours (P < .001 for both, compared with baseline). Both fasting FABP4 and nadir FABP4 correlated with obesity. Nadir FABP4 correlated also with insulin resistance parameters from frequently sampled intravenous glucose tolerance test and with inflammation. Nadir FFA, but not fasting FFA, correlated with the metabolic syndrome parameters. In conclusion, fasting FABP4 related to metabolic risk markers more strongly than fasting FFA. Nadir FABP4 and nadir FFA measured after glucose loading may provide better risk assessment than the fasting values.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1002-1007 |
| Number of pages | 6 |
| Journal | Metabolism: Clinical and Experimental |
| Volume | 58 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2009 |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
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Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers. / Karakas, Siddika E; Almario, Rogelio U.; Kim, Kyoungmi.
In: Metabolism: Clinical and Experimental, Vol. 58, No. 7, 07.2009, p. 1002-1007.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers
AU - Karakas, Siddika E
AU - Almario, Rogelio U.
AU - Kim, Kyoungmi
PY - 2009/7
Y1 - 2009/7
N2 - Fatty acid binding protein (FABP) 4 chaperones free fatty acids (FFAs) in the adipocytes during lipolysis. Serum FFA relates to metabolic syndrome, and serum FABP4 is emerging as a novel risk marker. In 36 overweight/obese women, serum FABP4 and FFA were measured hourly during 5-hour oral glucose tolerance test. Insulin resistance was determined using frequently sampled intravenous glucose tolerance test. Serum lipids and inflammation markers were measured at fasting. During oral glucose tolerance test, serum FABP4 decreased by 40%, reaching its nadir at 3 hours (from 45.3 ± 3.1 to 31.9 ± 1.6 ng/mL), and stayed below the baseline at 5 hours (35.9 ± 2.2 ng/mL) (P < .0001 for both, compared with the baseline). Serum FFA decreased by 10-fold, reaching a nadir at 2 hours (from 0.611 ± 0.033 to 0.067 ± 0.004 mmol/L), then rebounded to 0.816 ± 0.035 mmol/L at 5 hours (P < .001 for both, compared with baseline). Both fasting FABP4 and nadir FABP4 correlated with obesity. Nadir FABP4 correlated also with insulin resistance parameters from frequently sampled intravenous glucose tolerance test and with inflammation. Nadir FFA, but not fasting FFA, correlated with the metabolic syndrome parameters. In conclusion, fasting FABP4 related to metabolic risk markers more strongly than fasting FFA. Nadir FABP4 and nadir FFA measured after glucose loading may provide better risk assessment than the fasting values.
AB - Fatty acid binding protein (FABP) 4 chaperones free fatty acids (FFAs) in the adipocytes during lipolysis. Serum FFA relates to metabolic syndrome, and serum FABP4 is emerging as a novel risk marker. In 36 overweight/obese women, serum FABP4 and FFA were measured hourly during 5-hour oral glucose tolerance test. Insulin resistance was determined using frequently sampled intravenous glucose tolerance test. Serum lipids and inflammation markers were measured at fasting. During oral glucose tolerance test, serum FABP4 decreased by 40%, reaching its nadir at 3 hours (from 45.3 ± 3.1 to 31.9 ± 1.6 ng/mL), and stayed below the baseline at 5 hours (35.9 ± 2.2 ng/mL) (P < .0001 for both, compared with the baseline). Serum FFA decreased by 10-fold, reaching a nadir at 2 hours (from 0.611 ± 0.033 to 0.067 ± 0.004 mmol/L), then rebounded to 0.816 ± 0.035 mmol/L at 5 hours (P < .001 for both, compared with baseline). Both fasting FABP4 and nadir FABP4 correlated with obesity. Nadir FABP4 correlated also with insulin resistance parameters from frequently sampled intravenous glucose tolerance test and with inflammation. Nadir FFA, but not fasting FFA, correlated with the metabolic syndrome parameters. In conclusion, fasting FABP4 related to metabolic risk markers more strongly than fasting FFA. Nadir FABP4 and nadir FFA measured after glucose loading may provide better risk assessment than the fasting values.
UR - http://www.scopus.com/inward/record.url?scp=66349128493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66349128493&partnerID=8YFLogxK
U2 - 10.1016/j.metabol.2009.02.024
DO - 10.1016/j.metabol.2009.02.024
M3 - Article
C2 - 19394980
AN - SCOPUS:66349128493
VL - 58
SP - 1002
EP - 1007
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 7
ER -