Serum concentrations of α tocopherol, β3 carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus

G. W. Comstock, A. E. Burke, S. C. Hoffman, K. J. Helzlsouer, A. Bendich, A. T. Masi, E. P. Norkus, R. L. Malamet, M. Eric Gershwin

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Abstract

Objectives-Because oxidative damage has been implicated in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, this study was designed to see if serum concentrations of a tocopherol, β carotene, and retinol, substances believed to be involved in the prevention or repair of oxidative damage, might be lower among persons who develop rheumatoid arthritis or systemic lupus erythematosus than among those who do not. Methods-For this prospective case-control study, persons with rheumatoid arthritis and systemic lupus erythematosus that developed two to 15 years after donating blood for a serum bank in 1974 were designated as cases. For each case, four controls were selected from the serum bank donors, matched for race, sex, and age. Stored serum samples from cases and controls were assayed for a tocopherol, β carotene, and retinol. Results-Cases of both diseases had lower serum concentrations of a tocopherol, β carotene, and retinol in 1974 than their matched controls. For rheumatoid arthritis, the difference for β carotene (-29%) was statistically significant. Conclusions- These findings support those of a previous study that low antioxidant status is a risk factor for rheumatoid arthritis. They suggest a similar association for systemic lupus erythematosus.

Original languageEnglish (US)
Pages (from-to)323-325
Number of pages3
JournalAnnals of the Rheumatic Diseases
Volume56
Issue number5
StatePublished - 1997

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Tocopherols
Carotenoids
Vitamin A
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Serum
Rheumatoid Factor
Repair
Blood
Antioxidants
Case-Control Studies
Tissue Donors

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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Serum concentrations of α tocopherol, β3 carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus. / Comstock, G. W.; Burke, A. E.; Hoffman, S. C.; Helzlsouer, K. J.; Bendich, A.; Masi, A. T.; Norkus, E. P.; Malamet, R. L.; Gershwin, M. Eric.

In: Annals of the Rheumatic Diseases, Vol. 56, No. 5, 1997, p. 323-325.

Research output: Contribution to journalArticle

Comstock, GW, Burke, AE, Hoffman, SC, Helzlsouer, KJ, Bendich, A, Masi, AT, Norkus, EP, Malamet, RL & Gershwin, ME 1997, 'Serum concentrations of α tocopherol, β3 carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus', Annals of the Rheumatic Diseases, vol. 56, no. 5, pp. 323-325.
Comstock, G. W. ; Burke, A. E. ; Hoffman, S. C. ; Helzlsouer, K. J. ; Bendich, A. ; Masi, A. T. ; Norkus, E. P. ; Malamet, R. L. ; Gershwin, M. Eric. / Serum concentrations of α tocopherol, β3 carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus. In: Annals of the Rheumatic Diseases. 1997 ; Vol. 56, No. 5. pp. 323-325.
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