Serum biomarkers of polyfluoroalkyl compound exposure in young girls in Greater Cincinnati and the San Francisco Bay Area, USA

Susan M. Pinney, Frank M. Biro, Gayle C. Windham, Robert L. Herrick, Lusine Yaghjyan, Antonia M. Calafat, Paul Succop, Heidi Sucharew, Kathleen M. Ball, Kayoko Kato, Lawrence H. Kushi, Robert Bornschein

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

PFC serum concentrations were measured in 6-8 year-old girls in Greater Cincinnati (GC) (N = 353) and the San Francisco Bay Area (SFBA) (N = 351). PFOA median concentration was lower in the SFBA than GC (5.8 vs. 7.3 ng/mL). In GC, 48/51 girls living in one area had PFOA concentrations above the NHANES 95th percentile for children 12-19 years (8.4 ng/mL), median 22.0 ng/mL. The duration of being breast fed was associated with higher serum PFOA at both sites and with higher PFOS, PFHxS and Me-PFOSA-AcOH concentrations in GC. Correlations of the PFC analytes with each other suggest that a source upriver from GC may have contributed to exposures through drinking water, and water treatment with granular activated carbon filtration resulted in less exposure for SWO girls compared to those in NKY. PFOA has been characterized as a drinking water contaminant, and water treatment systems effective in removing PFCs will reduce body burdens.

Original languageEnglish (US)
Pages (from-to)327-334
Number of pages8
JournalEnvironmental Pollution
Volume184
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Biomonitoring
  • Children
  • Drinking water contaminants
  • Human milk
  • Polyfluoroalkyl compounds (PFCs)

ASJC Scopus subject areas

  • Pollution
  • Health, Toxicology and Mutagenesis
  • Toxicology

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  • Cite this

    Pinney, S. M., Biro, F. M., Windham, G. C., Herrick, R. L., Yaghjyan, L., Calafat, A. M., Succop, P., Sucharew, H., Ball, K. M., Kato, K., Kushi, L. H., & Bornschein, R. (2014). Serum biomarkers of polyfluoroalkyl compound exposure in young girls in Greater Cincinnati and the San Francisco Bay Area, USA. Environmental Pollution, 184, 327-334. https://doi.org/10.1016/j.envpol.2013.09.008