Serum beta-2-microglobulin estimation as an indicator of the glomerular filtration rate

I. Jialal, B. C. Nathoo, S. Bejai, S. M. Joubert

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Abstract

In 56 patients in whom the glomerular filtration rate (GFR) was estimated by the 51Cr-EDTA technique, serum creatinine and B2-microglobulin levels were also measured. In the 15 patients with a GFR of ≥ 80 ml/min, both serum creatinine and B2-microglobulin levels were within the relerence range. However, the B2-microglobulin level was elevated (>2,3 mg/l) in all 41 patients with a GFR of < 80 ml/min, while the serum creatinine levels was increased (> 133 μmol/l) in only 35 patients. In the remaining 6 patients, the creatinine values ranged from 75 to 125 μmol/l. It would therefore seem that serum B2-microglobulin assay is a more sensitive test than creatinine assay for detecting impaired renal function.

Original languageEnglish (US)
Pages (from-to)953-954
Number of pages2
JournalSouth African Medical Journal
Volume61
Issue number25
StatePublished - 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jialal, I., Nathoo, B. C., Bejai, S., & Joubert, S. M. (1982). Serum beta-2-microglobulin estimation as an indicator of the glomerular filtration rate. South African Medical Journal, 61(25), 953-954.