Serum autoantibodies for the diagnosis and management of autoimmune liver diseases

Maria Is Achenza, Francesca Meda, Enrico Brunetta, Carlo Selmi

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The spectrum of autoimmune liver diseases (AILD) includes primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis. The immunological mechanisms triggering the initiation and perpetuation of AILD remains unknown, while autoantigens are now recognized in most cases, and are generally nontraditional in their widespread distribution. Sensitive and specific methods for the detection of serum autoantibodies in patients affected by AILD represent a challenge for researchers and clinicians who desire to obtain an early and certain diagnosis as well as markers of disease control. To this regard, the use and interpretation of serum autoantibodies in AILD may be seen as paradigmatic for the large gaps in our knowledge based on the lack of true population-based studies. The present review article will critically discuss the available evidence on the use of autoantibody findings in the diagnosis or management of autoimmune liver disease.

Original languageEnglish (US)
Pages (from-to)717-729
Number of pages13
JournalExpert Review of Gastroenterology and Hepatology
Volume6
Issue number6
DOIs
StatePublished - Dec 2012
Externally publishedYes

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Keywords

  • autoimmune hepatitis
  • diagnosis
  • pathogenesis
  • primary biliary cirrhosis
  • primary sclerosing cholangitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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