Serum autoantibodies: A road map for the clinical hepatologist

Francesca Meda, Massimo Zuin, Pietro Invernizzi, Diego Vergani, Carlo Selmi

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The widespread use of serum autoantibodies in the practice of clinical hepatology has led to novel challenges in the interpretation of results obtained with routine techniques, such as indirect immunofluorescence (IIF) or with recombinant antigens. In fact, the laboratory methods are often overlooked factors in the interpretation of data by the bedside clinician despite being critical in the interpretation of data. Importantly, the sensitivity and specificity of these serum hallmarks are not defined in all cases. Taken altogether, these observations point towards the need for a systematic discussion of autoimmune serology in the clinical setting of everyday practice. The target of this review article is therefore, to illustrate the current knowledge and available experimental evidence to guide the diagnostic and prognostic decision making in autoimmune and viral chronic liver diseases.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalAutoimmunity
Volume41
Issue number1
DOIs
StatePublished - Feb 2008
Externally publishedYes

Keywords

  • Autoimmune hepatitis
  • Diagnosis
  • Pathogenesis
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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