Serum adiponectin and coronary heart disease risk in Older Black and White Americans

Alka M. Kanaya, Christina Wassel Fyr, Eric Vittinghoff, Peter J Havel, Matteo Cesari, Barbara Nicklas, Tamara Harris, Anne B. Newman, Suzanne Satterfield, Steve R. Cummings

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Context: Adiponectin may influence the risk of coronary heart disease (CHD) independently of traditional cardiovascular risk factors. Objective: Because body composition and adiponectin levels vary by race, we examined the relationship of adiponectin with prevalent and incident CHD in a cohort of older Black and White adults. Design and Setting: We conducted a cross-sectional and prospective cohort study at two U.S. clinical centers. Participants: Participants included 3075 well-functioning adults between ages 70 and 79 yr enrolled in the Health, Aging, and Body Composition study. Main Outcome Measures: Prevalent CHD was defined as history of myocardial infarction, coronary artery bypass graft, percutaneous coronary transluminal angioplasty, angina, or major electrocardiogram abnormalities. After excluding those with prevalent CHD, incident CHD was defined as hospitalized myocardial infarction or CHD death. Results: At baseline, 602 participants (19.6%) had CHD. During 6 yr of follow-up, 262 (10.6%) incident CH Devents occurred. Whites had higher median adiponectin than Blacks (12 vs. 8 μg/ml, P < 0.001). Race modified the effect of adiponectin (P for interaction was 0.002 for prevalent CHD, and P = 0.02 for incident CHD). Among Whites, an inverse association of adiponectin with CHD was explained by high-density lipoprotein and glucose. Among Blacks, a doubling of adiponectin was associated with a 40% higher risk of both prevalent CHD (odds ratio, 1.41; 95% confidence interval, 1.11-1.78) and incident CHD (hazards ratio, 1.37; 95% confidence interval, 1.01-1.87) after adjusting for explanatory variables. Conclusion: High circulating concentrations of adiponectin were associated with higher risk of CHD in older Blacks, even accounting for traditional CHD risk factors.

Original languageEnglish (US)
Pages (from-to)5044-5050
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number12
DOIs
StatePublished - Dec 2006

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Adiponectin
Coronary Disease
Serum
hydroquinone
Body Composition
Myocardial Infarction
Confidence Intervals
Coronary Balloon Angioplasty
HDL Lipoproteins
Chemical analysis
Electrocardiography
Grafts
Coronary Artery Bypass
Hazards
Cohort Studies

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Serum adiponectin and coronary heart disease risk in Older Black and White Americans. / Kanaya, Alka M.; Fyr, Christina Wassel; Vittinghoff, Eric; Havel, Peter J; Cesari, Matteo; Nicklas, Barbara; Harris, Tamara; Newman, Anne B.; Satterfield, Suzanne; Cummings, Steve R.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 91, No. 12, 12.2006, p. 5044-5050.

Research output: Contribution to journalArticle

Kanaya, AM, Fyr, CW, Vittinghoff, E, Havel, PJ, Cesari, M, Nicklas, B, Harris, T, Newman, AB, Satterfield, S & Cummings, SR 2006, 'Serum adiponectin and coronary heart disease risk in Older Black and White Americans', Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 12, pp. 5044-5050. https://doi.org/10.1210/jc.2006-0107
Kanaya, Alka M. ; Fyr, Christina Wassel ; Vittinghoff, Eric ; Havel, Peter J ; Cesari, Matteo ; Nicklas, Barbara ; Harris, Tamara ; Newman, Anne B. ; Satterfield, Suzanne ; Cummings, Steve R. / Serum adiponectin and coronary heart disease risk in Older Black and White Americans. In: Journal of Clinical Endocrinology and Metabolism. 2006 ; Vol. 91, No. 12. pp. 5044-5050.
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abstract = "Context: Adiponectin may influence the risk of coronary heart disease (CHD) independently of traditional cardiovascular risk factors. Objective: Because body composition and adiponectin levels vary by race, we examined the relationship of adiponectin with prevalent and incident CHD in a cohort of older Black and White adults. Design and Setting: We conducted a cross-sectional and prospective cohort study at two U.S. clinical centers. Participants: Participants included 3075 well-functioning adults between ages 70 and 79 yr enrolled in the Health, Aging, and Body Composition study. Main Outcome Measures: Prevalent CHD was defined as history of myocardial infarction, coronary artery bypass graft, percutaneous coronary transluminal angioplasty, angina, or major electrocardiogram abnormalities. After excluding those with prevalent CHD, incident CHD was defined as hospitalized myocardial infarction or CHD death. Results: At baseline, 602 participants (19.6{\%}) had CHD. During 6 yr of follow-up, 262 (10.6{\%}) incident CH Devents occurred. Whites had higher median adiponectin than Blacks (12 vs. 8 μg/ml, P < 0.001). Race modified the effect of adiponectin (P for interaction was 0.002 for prevalent CHD, and P = 0.02 for incident CHD). Among Whites, an inverse association of adiponectin with CHD was explained by high-density lipoprotein and glucose. Among Blacks, a doubling of adiponectin was associated with a 40{\%} higher risk of both prevalent CHD (odds ratio, 1.41; 95{\%} confidence interval, 1.11-1.78) and incident CHD (hazards ratio, 1.37; 95{\%} confidence interval, 1.01-1.87) after adjusting for explanatory variables. Conclusion: High circulating concentrations of adiponectin were associated with higher risk of CHD in older Blacks, even accounting for traditional CHD risk factors.",
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AU - Kanaya, Alka M.

AU - Fyr, Christina Wassel

AU - Vittinghoff, Eric

AU - Havel, Peter J

AU - Cesari, Matteo

AU - Nicklas, Barbara

AU - Harris, Tamara

AU - Newman, Anne B.

AU - Satterfield, Suzanne

AU - Cummings, Steve R.

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N2 - Context: Adiponectin may influence the risk of coronary heart disease (CHD) independently of traditional cardiovascular risk factors. Objective: Because body composition and adiponectin levels vary by race, we examined the relationship of adiponectin with prevalent and incident CHD in a cohort of older Black and White adults. Design and Setting: We conducted a cross-sectional and prospective cohort study at two U.S. clinical centers. Participants: Participants included 3075 well-functioning adults between ages 70 and 79 yr enrolled in the Health, Aging, and Body Composition study. Main Outcome Measures: Prevalent CHD was defined as history of myocardial infarction, coronary artery bypass graft, percutaneous coronary transluminal angioplasty, angina, or major electrocardiogram abnormalities. After excluding those with prevalent CHD, incident CHD was defined as hospitalized myocardial infarction or CHD death. Results: At baseline, 602 participants (19.6%) had CHD. During 6 yr of follow-up, 262 (10.6%) incident CH Devents occurred. Whites had higher median adiponectin than Blacks (12 vs. 8 μg/ml, P < 0.001). Race modified the effect of adiponectin (P for interaction was 0.002 for prevalent CHD, and P = 0.02 for incident CHD). Among Whites, an inverse association of adiponectin with CHD was explained by high-density lipoprotein and glucose. Among Blacks, a doubling of adiponectin was associated with a 40% higher risk of both prevalent CHD (odds ratio, 1.41; 95% confidence interval, 1.11-1.78) and incident CHD (hazards ratio, 1.37; 95% confidence interval, 1.01-1.87) after adjusting for explanatory variables. Conclusion: High circulating concentrations of adiponectin were associated with higher risk of CHD in older Blacks, even accounting for traditional CHD risk factors.

AB - Context: Adiponectin may influence the risk of coronary heart disease (CHD) independently of traditional cardiovascular risk factors. Objective: Because body composition and adiponectin levels vary by race, we examined the relationship of adiponectin with prevalent and incident CHD in a cohort of older Black and White adults. Design and Setting: We conducted a cross-sectional and prospective cohort study at two U.S. clinical centers. Participants: Participants included 3075 well-functioning adults between ages 70 and 79 yr enrolled in the Health, Aging, and Body Composition study. Main Outcome Measures: Prevalent CHD was defined as history of myocardial infarction, coronary artery bypass graft, percutaneous coronary transluminal angioplasty, angina, or major electrocardiogram abnormalities. After excluding those with prevalent CHD, incident CHD was defined as hospitalized myocardial infarction or CHD death. Results: At baseline, 602 participants (19.6%) had CHD. During 6 yr of follow-up, 262 (10.6%) incident CH Devents occurred. Whites had higher median adiponectin than Blacks (12 vs. 8 μg/ml, P < 0.001). Race modified the effect of adiponectin (P for interaction was 0.002 for prevalent CHD, and P = 0.02 for incident CHD). Among Whites, an inverse association of adiponectin with CHD was explained by high-density lipoprotein and glucose. Among Blacks, a doubling of adiponectin was associated with a 40% higher risk of both prevalent CHD (odds ratio, 1.41; 95% confidence interval, 1.11-1.78) and incident CHD (hazards ratio, 1.37; 95% confidence interval, 1.01-1.87) after adjusting for explanatory variables. Conclusion: High circulating concentrations of adiponectin were associated with higher risk of CHD in older Blacks, even accounting for traditional CHD risk factors.

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