Serum Adipokine Concentrations in Dogs with Acute Pancreatitis

J. Paek, J. H. Kang, H. S. Kim, I. Lee, Kyoung Won Seo, M. P. Yang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Limited information is available about the role of adipokines in the development and progression of acute pancreatitis (AP) in dogs. Objectives: To determine whether the circulating concentrations of adipokines differed between healthy dogs and dogs with AP, and whether the circulating concentrations differed between AP survivors and AP nonsurvivors. Animals: Twenty-eight healthy dogs and 25 client-owned dogs with AP. Methods: Prospective observational cohort study of 25 client-owned dogs with newly diagnosed AP and 28 otherwise healthy dogs with similar body condition scores. The serum concentrations of leptin, adiponectin, resistin, visfatin, interleukin (IL)-1β, IL-6, IL-10, IL-18, and tumor necrosis factor (TNF)-α were measured. Results: The serum concentrations of leptin (P =.0021), resistin (P =.0010), visfatin (P <.0001), IL-1β (P <.0001), IL-6 (P =.0002), IL-10 (P <.0001), and IL-18 (P <.0001) were significantly higher in dogs with AP than healthy dogs, whereas the adiponectin concentration (P =.0011) was significantly lower. There were significant differences in the serum concentrations of leptin (P =.028) and adiponectin (P =.046) in survivors and nonsurvivors. After the disappearance of clinical signs, the concentrations of resistin (P =.037) and IL-1β (P =.027) decreased significantly, whereas the serum concentrations of leptin (P >.999), adiponectin (P =.11), visfatin (P =.83), IL-6 (P =.82), IL-10 (P =.82), IL-18 (P =.56), and TNF-α (P =.94) did not differ significantly. Conclusion and Clinical Importance: This study showed that dysregulation of adipokines might be involved in the pathogenesis of AP. In addition, leptin and adiponectin are likely to be associated with mortality rate in AP.

Original languageEnglish (US)
Pages (from-to)1760-1769
Number of pages10
JournalJournal of Veterinary Internal Medicine
Volume28
Issue number6
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

adipokines
Adipokines
pancreatitis
Pancreatitis
Dogs
nicotinamide phosphoribosyltransferase
dogs
Nicotinamide Phosphoribosyltransferase
Serum
adiponectin
Adiponectin
Leptin
leptin
resistin
Resistin
interleukin-18
Interleukin-18
tumor necrosis factors
interleukin-10
interleukin-6

Keywords

  • Adiponectin
  • Canine
  • Cytokine
  • Leptin
  • Resistin
  • Visfatin

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Serum Adipokine Concentrations in Dogs with Acute Pancreatitis. / Paek, J.; Kang, J. H.; Kim, H. S.; Lee, I.; Seo, Kyoung Won; Yang, M. P.

In: Journal of Veterinary Internal Medicine, Vol. 28, No. 6, 01.01.2014, p. 1760-1769.

Research output: Contribution to journalArticle

Paek, J. ; Kang, J. H. ; Kim, H. S. ; Lee, I. ; Seo, Kyoung Won ; Yang, M. P. / Serum Adipokine Concentrations in Dogs with Acute Pancreatitis. In: Journal of Veterinary Internal Medicine. 2014 ; Vol. 28, No. 6. pp. 1760-1769.
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T1 - Serum Adipokine Concentrations in Dogs with Acute Pancreatitis

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AU - Kang, J. H.

AU - Kim, H. S.

AU - Lee, I.

AU - Seo, Kyoung Won

AU - Yang, M. P.

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N2 - Background: Limited information is available about the role of adipokines in the development and progression of acute pancreatitis (AP) in dogs. Objectives: To determine whether the circulating concentrations of adipokines differed between healthy dogs and dogs with AP, and whether the circulating concentrations differed between AP survivors and AP nonsurvivors. Animals: Twenty-eight healthy dogs and 25 client-owned dogs with AP. Methods: Prospective observational cohort study of 25 client-owned dogs with newly diagnosed AP and 28 otherwise healthy dogs with similar body condition scores. The serum concentrations of leptin, adiponectin, resistin, visfatin, interleukin (IL)-1β, IL-6, IL-10, IL-18, and tumor necrosis factor (TNF)-α were measured. Results: The serum concentrations of leptin (P =.0021), resistin (P =.0010), visfatin (P <.0001), IL-1β (P <.0001), IL-6 (P =.0002), IL-10 (P <.0001), and IL-18 (P <.0001) were significantly higher in dogs with AP than healthy dogs, whereas the adiponectin concentration (P =.0011) was significantly lower. There were significant differences in the serum concentrations of leptin (P =.028) and adiponectin (P =.046) in survivors and nonsurvivors. After the disappearance of clinical signs, the concentrations of resistin (P =.037) and IL-1β (P =.027) decreased significantly, whereas the serum concentrations of leptin (P >.999), adiponectin (P =.11), visfatin (P =.83), IL-6 (P =.82), IL-10 (P =.82), IL-18 (P =.56), and TNF-α (P =.94) did not differ significantly. Conclusion and Clinical Importance: This study showed that dysregulation of adipokines might be involved in the pathogenesis of AP. In addition, leptin and adiponectin are likely to be associated with mortality rate in AP.

AB - Background: Limited information is available about the role of adipokines in the development and progression of acute pancreatitis (AP) in dogs. Objectives: To determine whether the circulating concentrations of adipokines differed between healthy dogs and dogs with AP, and whether the circulating concentrations differed between AP survivors and AP nonsurvivors. Animals: Twenty-eight healthy dogs and 25 client-owned dogs with AP. Methods: Prospective observational cohort study of 25 client-owned dogs with newly diagnosed AP and 28 otherwise healthy dogs with similar body condition scores. The serum concentrations of leptin, adiponectin, resistin, visfatin, interleukin (IL)-1β, IL-6, IL-10, IL-18, and tumor necrosis factor (TNF)-α were measured. Results: The serum concentrations of leptin (P =.0021), resistin (P =.0010), visfatin (P <.0001), IL-1β (P <.0001), IL-6 (P =.0002), IL-10 (P <.0001), and IL-18 (P <.0001) were significantly higher in dogs with AP than healthy dogs, whereas the adiponectin concentration (P =.0011) was significantly lower. There were significant differences in the serum concentrations of leptin (P =.028) and adiponectin (P =.046) in survivors and nonsurvivors. After the disappearance of clinical signs, the concentrations of resistin (P =.037) and IL-1β (P =.027) decreased significantly, whereas the serum concentrations of leptin (P >.999), adiponectin (P =.11), visfatin (P =.83), IL-6 (P =.82), IL-10 (P =.82), IL-18 (P =.56), and TNF-α (P =.94) did not differ significantly. Conclusion and Clinical Importance: This study showed that dysregulation of adipokines might be involved in the pathogenesis of AP. In addition, leptin and adiponectin are likely to be associated with mortality rate in AP.

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KW - Resistin

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