Serum 25-hydroxyvitamin D concentrations in dogs with osteosarcoma do not differ from those of age- and weight-matched control dogs

Jennifer Willcox, Catherine Hammett-Stabler, Marlene L. Hauck

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Vitamin D concentrations show an inverse correlation with incidence of certain tumors in people and dogs. Additionally, human osteosarcoma has been associated with dysregulation of vitamin D-dependent pathways. The study objective was to compare serum 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in 20 dogs with osteosarcoma to age- and weight-matched control dogs. We hypothesized that dogs with osteosarcoma would have lower serum 25-hydroxyvitamin D than control dogs. The mean 25-hydroxyvitamin D3 concentrations for dogs with osteosarcoma and matched-controls were 34.95 ng/mL and 33.85 ng/mL, respectively (P = 0.784). Based on these data, 25-hydroxyvitamin D insufficiency might not be important in the pathogenesis of canine osteosarcoma.

Original languageEnglish (US)
Pages (from-to)132-133
Number of pages2
JournalVeterinary Journal
Volume217
DOIs
StatePublished - Nov 1 2016

Keywords

  • Bone
  • Cancer
  • Canine
  • Osteosarcoma
  • Vitamin D

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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