Serum 17α-hydroxyprogesterone concentrations during the reproductive cycle in healthy dogs and dogs with hyperadrenocorticism

C. Brömel, Edward C Feldman, Autumn P. Davidson, Richard W Nelson, Philip H Kass, Alejandro Esteller Vico, Philippe Labelle, Coralie J. Munro, Alan J Conley

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective-To determine concentrations of 17α-hydroxyprogesterone (17OHP) in serum of healthy bitches during various stages of the reproductive cycle and in bitches with hyperadrenocorticism and to compare the dynamics of 17OH P with those of progesterone. Design-Prospective evaluation study. Animals-15 healthy sexually intact bitches and 28 spayed bitches with hyperadrenocorticism. Procedures-11 healthy bitches were evaluated during estrus, nonpregnant diestrus, and anestrus (group 1); 4 other healthy bitches were evaluated during pregnancy and after ovariohysterectomy (group 2). Cycle stages were determined via physical examination, vaginal cytologic evaluation, and serum progesterone concentration. Bitches with hyperadrenocorticism were evaluated once at the time of diagnosis (group 3). Serum hormone concentrations were determined with immunoassays. Results-In group 1, the serum 17OHP concentration was significantly higher in diestrus (median, 1.8 ng/mL) than in estrus (median, 1.1 ng/mL) and anestrus (median, 0.2 ng/mL) and higher in estrus than in anestrus. Changes in serum progesterone concentrations accounted for 22% (estrus) or 23% (diestrus) of the variation in serum 17OHP concentrations. In group 2, 17OHP and progesterone concentrations were significantly higher during pregnancy than after ovariohysterectomy. The serum 17OHP concentration in group 3 was significantly lower (median, 0.2 ng/mL) than in group 1 in estrus and diestrus and in group 2 during pregnancy (median, 0.7 ng/mL) but was not different from 17OHP concentrations in anestrus or after ovariohysterectomy (median, 0.2 ng/mL). Conclusions and Clinical Relevance-Serum 17OHP concentrations in healthy bitches increased during estrus, diestrus, and pregnancy and at those times were higher than in spayed bitches with hyperadrenocorticism.

Original languageEnglish (US)
Pages (from-to)1208-1214
Number of pages7
JournalJournal of the American Veterinary Medical Association
Volume236
Issue number11
DOIs
StatePublished - Jun 1 2010

ASJC Scopus subject areas

  • veterinary(all)

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