Serotonin3 antagonists block aversion to saccharin in an amino acid- imbalanced diet

V. R. Terry-Nathan, D. W. Gietzen, Quinton Rogers

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Conditioned taste aversion presumably plays a role in the anorectic responses to amino acid-imbalanced diets that induce acute amino acid deficiency. The serotonin3 (5-HT3) receptor antagonists, tropisetron (Trop), MDL-72222 (MDL), and ondansetron, increase intake of imbalanced amino acid diets. Therefore, we tested whether 5-HT3 receptor antagonists would block an aversion to powdered saccharin after it was included in an amino acid-imbalanced diet. Rats were given an intraperitoneal injection of Trop, MDL, or vehicle (Veh), just before introducing one of four diets: imbalanced amino acid diet ± saccharin (Imb or Imb(Sac)) or a balanced (corrected) diet ± saccharin (Cor or Cor(Sac)). Subsequent aversion to saccharin was shown in preference tests using Cor and Cor(Sac). Saccharin preference was significantly decreased (8.3% on test day 1) in the Veh/Imb(Sac) group, but the Trop/Imb(Sac) group's saccharin preference (57.8%) was similar to controls (49.6-70.3%); MDL also blocked the aversion to saccharin after Imb(Sac). This confirms previous reports of conditional taste aversions with amino acid limitation and suggests a role for the 5-HT3 receptor in the development of these aversions.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number5 37-5
StatePublished - Jan 1 1995


  • amino acid deficiency
  • conditioned taste aversion
  • feeding behavior
  • ICS-205-930
  • MDL-72222
  • nutrition
  • ondansetron
  • rat
  • serotonin receptor
  • tropisetron

ASJC Scopus subject areas

  • Physiology
  • Agricultural and Biological Sciences(all)
  • Medicine(all)


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