Abstract
Background: The short (S) allele of the serotonin transporter gene-linked polymorphic region (5HTTLPR) has been associated with poorer antidepressant response in major depressive disorder (MDD) and with antidepressant-induced mania. This study investigated a possible association with treatment-emergent insomnia or agitation. Methods: Thirty-six outpatients with MDD were genotyped at 5HTTLPR and treated with open-label fluoxetine up to 60 mg/day. Treatment-emergent adverse effects were assessed at each study visit. Results: Of nine subjects homozygous for the "S" allele, seven (78%) developed new or worsening insomnia, versus 6 of 27 (22%) non-"S"-homozygous subjects (Fisher's exact p = .005). Similarly, six of nine subjects homozygous for the "S" allele (67%) developed agitation, versus 2 of 27 (7%) of non-"S"-homozygous subjects (Fisher's exact p = .001). Conclusions: The "S" allele of the 5HTTLPR may identify patients at risk for developing insomnia or agitation with fluoxetine treatment. This preliminary result requires confirmation in larger samples.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 879-883 |
| Number of pages | 5 |
| Journal | Biological Psychiatry |
| Volume | 54 |
| Issue number | 9 |
| DOIs | |
| State | Published - Nov 1 2003 |
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Keywords
- Adverse event
- Agitation
- Depression
- Fluoxetine
- Insomnia
- Serotonin transporter
ASJC Scopus subject areas
- Biological Psychiatry
Cite this
Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment. / Perlis, Roy H.; Mischoulon, David; Smoller, Jordan W.; Wan, Yu-Jui Yvonne; Lamon-Fava, Stefania; Lin, Keh Ming; Rosenbaum, Jerrold F.; Fava, Maurizio.
In: Biological Psychiatry, Vol. 54, No. 9, 01.11.2003, p. 879-883.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment
AU - Perlis, Roy H.
AU - Mischoulon, David
AU - Smoller, Jordan W.
AU - Wan, Yu-Jui Yvonne
AU - Lamon-Fava, Stefania
AU - Lin, Keh Ming
AU - Rosenbaum, Jerrold F.
AU - Fava, Maurizio
PY - 2003/11/1
Y1 - 2003/11/1
N2 - Background: The short (S) allele of the serotonin transporter gene-linked polymorphic region (5HTTLPR) has been associated with poorer antidepressant response in major depressive disorder (MDD) and with antidepressant-induced mania. This study investigated a possible association with treatment-emergent insomnia or agitation. Methods: Thirty-six outpatients with MDD were genotyped at 5HTTLPR and treated with open-label fluoxetine up to 60 mg/day. Treatment-emergent adverse effects were assessed at each study visit. Results: Of nine subjects homozygous for the "S" allele, seven (78%) developed new or worsening insomnia, versus 6 of 27 (22%) non-"S"-homozygous subjects (Fisher's exact p = .005). Similarly, six of nine subjects homozygous for the "S" allele (67%) developed agitation, versus 2 of 27 (7%) of non-"S"-homozygous subjects (Fisher's exact p = .001). Conclusions: The "S" allele of the 5HTTLPR may identify patients at risk for developing insomnia or agitation with fluoxetine treatment. This preliminary result requires confirmation in larger samples.
AB - Background: The short (S) allele of the serotonin transporter gene-linked polymorphic region (5HTTLPR) has been associated with poorer antidepressant response in major depressive disorder (MDD) and with antidepressant-induced mania. This study investigated a possible association with treatment-emergent insomnia or agitation. Methods: Thirty-six outpatients with MDD were genotyped at 5HTTLPR and treated with open-label fluoxetine up to 60 mg/day. Treatment-emergent adverse effects were assessed at each study visit. Results: Of nine subjects homozygous for the "S" allele, seven (78%) developed new or worsening insomnia, versus 6 of 27 (22%) non-"S"-homozygous subjects (Fisher's exact p = .005). Similarly, six of nine subjects homozygous for the "S" allele (67%) developed agitation, versus 2 of 27 (7%) of non-"S"-homozygous subjects (Fisher's exact p = .001). Conclusions: The "S" allele of the 5HTTLPR may identify patients at risk for developing insomnia or agitation with fluoxetine treatment. This preliminary result requires confirmation in larger samples.
KW - Adverse event
KW - Agitation
KW - Depression
KW - Fluoxetine
KW - Insomnia
KW - Serotonin transporter
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UR - http://www.scopus.com/inward/citedby.url?scp=0142157564&partnerID=8YFLogxK
U2 - 10.1016/S0006-3223(03)00424-4
DO - 10.1016/S0006-3223(03)00424-4
M3 - Article
C2 - 14573314
AN - SCOPUS:0142157564
VL - 54
SP - 879
EP - 883
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 9
ER -