Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques

E. L. Kinnally, E. R. Tarara, W. A. Mason, S. P. Mendoza, K. Abel, Leslie A Lyons, J. P. Capitanio

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Serotonin transporter (5-HTT) expression patterns may contribute to the risk for adverse psychological outcomes following early life stress. The present study investigated whether two types of early life stress, maternal and social aggression, and a serotonin transporter gene promoter polymorphism (rh5-HTTLPR) predicted lower post-stressor peripheral blood mononuclear cell (PBMC) 5-HTT expression in infant rhesus macaques. We further probed the relationships among these factors and infant behavioral disinhibition within a stressful situation. Fifty-three infants residing with mothers in large, complex social groups were observed over the first 12 postnatal weeks, during which time the rate of aggression received by the infant from their mothers and social group members was recorded. At 90-120 days of age, infants underwent a 25-h maternal separation/biobehavioral assessment, which included standardized behavioral assessments and blood sampling. Infants' rh5-HTTLPR genotypes were determined, and infant 5-HTT expression was quantified from PBMCs collected 8 h after separation. Receipt of aggression from the mother, but not from social group members, was associated with lower post-stressor 5-HTT expression. Lower post-stressor 5-HTT expression, but not receipt of aggression, was associated with disinhibited behavior during assessment. Rh5-HTTLPR genotype was unrelated to any measure. We conclude that 5-HTT regulation is linked with specific, presumably stressful early experiences in infant rhesus macaques. Further, 5-HTT expression predicted behavioral disinhibition, presumably via parallel processes that operate in the brain.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalGenes, Brain and Behavior
Volume9
Issue number1
DOIs
StatePublished - Feb 2010
Externally publishedYes

Fingerprint

Infant Behavior
Serotonin Plasma Membrane Transport Proteins
Macaca mulatta
Psychological Stress
Aggression
Mothers
Genotype
Blood Cells
Psychology

Keywords

  • Behavioral disinhibition
  • Development
  • Early life stress
  • Genotype
  • Rhesus macaque
  • Serotonin transporter

ASJC Scopus subject areas

  • Genetics
  • Neurology
  • Behavioral Neuroscience

Cite this

Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques. / Kinnally, E. L.; Tarara, E. R.; Mason, W. A.; Mendoza, S. P.; Abel, K.; Lyons, Leslie A; Capitanio, J. P.

In: Genes, Brain and Behavior, Vol. 9, No. 1, 02.2010, p. 45-52.

Research output: Contribution to journalArticle

Kinnally, E. L. ; Tarara, E. R. ; Mason, W. A. ; Mendoza, S. P. ; Abel, K. ; Lyons, Leslie A ; Capitanio, J. P. / Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques. In: Genes, Brain and Behavior. 2010 ; Vol. 9, No. 1. pp. 45-52.
@article{e1ef31c8fbbb4547bc40091f36177619,
title = "Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques",
abstract = "Serotonin transporter (5-HTT) expression patterns may contribute to the risk for adverse psychological outcomes following early life stress. The present study investigated whether two types of early life stress, maternal and social aggression, and a serotonin transporter gene promoter polymorphism (rh5-HTTLPR) predicted lower post-stressor peripheral blood mononuclear cell (PBMC) 5-HTT expression in infant rhesus macaques. We further probed the relationships among these factors and infant behavioral disinhibition within a stressful situation. Fifty-three infants residing with mothers in large, complex social groups were observed over the first 12 postnatal weeks, during which time the rate of aggression received by the infant from their mothers and social group members was recorded. At 90-120 days of age, infants underwent a 25-h maternal separation/biobehavioral assessment, which included standardized behavioral assessments and blood sampling. Infants' rh5-HTTLPR genotypes were determined, and infant 5-HTT expression was quantified from PBMCs collected 8 h after separation. Receipt of aggression from the mother, but not from social group members, was associated with lower post-stressor 5-HTT expression. Lower post-stressor 5-HTT expression, but not receipt of aggression, was associated with disinhibited behavior during assessment. Rh5-HTTLPR genotype was unrelated to any measure. We conclude that 5-HTT regulation is linked with specific, presumably stressful early experiences in infant rhesus macaques. Further, 5-HTT expression predicted behavioral disinhibition, presumably via parallel processes that operate in the brain.",
keywords = "Behavioral disinhibition, Development, Early life stress, Genotype, Rhesus macaque, Serotonin transporter",
author = "Kinnally, {E. L.} and Tarara, {E. R.} and Mason, {W. A.} and Mendoza, {S. P.} and K. Abel and Lyons, {Leslie A} and Capitanio, {J. P.}",
year = "2010",
month = "2",
doi = "10.1111/j.1601-183X.2009.00533.x",
language = "English (US)",
volume = "9",
pages = "45--52",
journal = "Genes, Brain and Behavior",
issn = "1601-1848",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques

AU - Kinnally, E. L.

AU - Tarara, E. R.

AU - Mason, W. A.

AU - Mendoza, S. P.

AU - Abel, K.

AU - Lyons, Leslie A

AU - Capitanio, J. P.

PY - 2010/2

Y1 - 2010/2

N2 - Serotonin transporter (5-HTT) expression patterns may contribute to the risk for adverse psychological outcomes following early life stress. The present study investigated whether two types of early life stress, maternal and social aggression, and a serotonin transporter gene promoter polymorphism (rh5-HTTLPR) predicted lower post-stressor peripheral blood mononuclear cell (PBMC) 5-HTT expression in infant rhesus macaques. We further probed the relationships among these factors and infant behavioral disinhibition within a stressful situation. Fifty-three infants residing with mothers in large, complex social groups were observed over the first 12 postnatal weeks, during which time the rate of aggression received by the infant from their mothers and social group members was recorded. At 90-120 days of age, infants underwent a 25-h maternal separation/biobehavioral assessment, which included standardized behavioral assessments and blood sampling. Infants' rh5-HTTLPR genotypes were determined, and infant 5-HTT expression was quantified from PBMCs collected 8 h after separation. Receipt of aggression from the mother, but not from social group members, was associated with lower post-stressor 5-HTT expression. Lower post-stressor 5-HTT expression, but not receipt of aggression, was associated with disinhibited behavior during assessment. Rh5-HTTLPR genotype was unrelated to any measure. We conclude that 5-HTT regulation is linked with specific, presumably stressful early experiences in infant rhesus macaques. Further, 5-HTT expression predicted behavioral disinhibition, presumably via parallel processes that operate in the brain.

AB - Serotonin transporter (5-HTT) expression patterns may contribute to the risk for adverse psychological outcomes following early life stress. The present study investigated whether two types of early life stress, maternal and social aggression, and a serotonin transporter gene promoter polymorphism (rh5-HTTLPR) predicted lower post-stressor peripheral blood mononuclear cell (PBMC) 5-HTT expression in infant rhesus macaques. We further probed the relationships among these factors and infant behavioral disinhibition within a stressful situation. Fifty-three infants residing with mothers in large, complex social groups were observed over the first 12 postnatal weeks, during which time the rate of aggression received by the infant from their mothers and social group members was recorded. At 90-120 days of age, infants underwent a 25-h maternal separation/biobehavioral assessment, which included standardized behavioral assessments and blood sampling. Infants' rh5-HTTLPR genotypes were determined, and infant 5-HTT expression was quantified from PBMCs collected 8 h after separation. Receipt of aggression from the mother, but not from social group members, was associated with lower post-stressor 5-HTT expression. Lower post-stressor 5-HTT expression, but not receipt of aggression, was associated with disinhibited behavior during assessment. Rh5-HTTLPR genotype was unrelated to any measure. We conclude that 5-HTT regulation is linked with specific, presumably stressful early experiences in infant rhesus macaques. Further, 5-HTT expression predicted behavioral disinhibition, presumably via parallel processes that operate in the brain.

KW - Behavioral disinhibition

KW - Development

KW - Early life stress

KW - Genotype

KW - Rhesus macaque

KW - Serotonin transporter

UR - http://www.scopus.com/inward/record.url?scp=75749132798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75749132798&partnerID=8YFLogxK

U2 - 10.1111/j.1601-183X.2009.00533.x

DO - 10.1111/j.1601-183X.2009.00533.x

M3 - Article

VL - 9

SP - 45

EP - 52

JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

SN - 1601-1848

IS - 1

ER -