Seroreversion in human immunodeficiency virus-exposed but uninfected infants

C. J. Chantry, E. R. Cooper, S. I. Pelton, C. Zorilla, G. V. Hillyer, C. Diaz

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The goal of this study was to describe seroreversion (SR) in a cohort of human immunodeficiency virus-exposed but uninfected infants. Groups of patients who seroreverted very early or late were examined for salient clinical and immunologic characteristics of the mother or infant. The mean time (± s.d.) to seroreversion by enzyme-linked immunoabsorbent assay (ELISA) was 50.1 ± 14.8 weeks, or 11.6 months (n = 84); the range of times to antibody loss by ELISA was 17.9 to 82.0 weeks. The mean time to seroreversion by Western blot was 68.3 ± 12.6 weeks, or 15.8 months (n = 51), with a range of 44.9 to 94.1 weeks. Initial anti-human immunodeficiency virus titer as measured by cord blood ELISA optical density (OD) was found to relate significantly to mean time to seroreversion. No relationship to time to seroreversion was demonstrated for gestational age, maternal or neonatal serum immunoglobulin concentrations, maternal CD4 cell counts, maternal alcohol consumption, infantile diarrhea or failure to thrive. The lengthy time to seroreversion seen here demonstrates the 1994 revised Centers for Disease Control and Prevention definition of human immunodeficiency virus infection (based on seropositivity by both ELISA and confirmatory tests persisting beyond 18 months of age) to be accurate in our population. We recommend Western blot testing be used as confirmation for positive ELISAs only after 18 months of age.

Original languageEnglish (US)
Pages (from-to)382-387
Number of pages6
JournalPediatric Infectious Disease Journal
Volume14
Issue number5
StatePublished - 1995
Externally publishedYes

Fingerprint

HIV
Mothers
Enzymes
Western Blotting
Surrogate Mothers
Infantile Diarrhea
Failure to Thrive
Virus Diseases
Centers for Disease Control and Prevention (U.S.)
CD4 Lymphocyte Count
Viral Load
Fetal Blood
Alcohol Drinking
Gestational Age
Immunoglobulins
Enzyme-Linked Immunosorbent Assay
Antibodies
Serum
Population

Keywords

  • Human immunodeficiency virus
  • natural history
  • perinatal transmission
  • seroreversion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

Cite this

Chantry, C. J., Cooper, E. R., Pelton, S. I., Zorilla, C., Hillyer, G. V., & Diaz, C. (1995). Seroreversion in human immunodeficiency virus-exposed but uninfected infants. Pediatric Infectious Disease Journal, 14(5), 382-387.

Seroreversion in human immunodeficiency virus-exposed but uninfected infants. / Chantry, C. J.; Cooper, E. R.; Pelton, S. I.; Zorilla, C.; Hillyer, G. V.; Diaz, C.

In: Pediatric Infectious Disease Journal, Vol. 14, No. 5, 1995, p. 382-387.

Research output: Contribution to journalArticle

Chantry, CJ, Cooper, ER, Pelton, SI, Zorilla, C, Hillyer, GV & Diaz, C 1995, 'Seroreversion in human immunodeficiency virus-exposed but uninfected infants', Pediatric Infectious Disease Journal, vol. 14, no. 5, pp. 382-387.
Chantry, C. J. ; Cooper, E. R. ; Pelton, S. I. ; Zorilla, C. ; Hillyer, G. V. ; Diaz, C. / Seroreversion in human immunodeficiency virus-exposed but uninfected infants. In: Pediatric Infectious Disease Journal. 1995 ; Vol. 14, No. 5. pp. 382-387.
@article{98d6fb87e56f479598a40ee47ddb9e13,
title = "Seroreversion in human immunodeficiency virus-exposed but uninfected infants",
abstract = "The goal of this study was to describe seroreversion (SR) in a cohort of human immunodeficiency virus-exposed but uninfected infants. Groups of patients who seroreverted very early or late were examined for salient clinical and immunologic characteristics of the mother or infant. The mean time (± s.d.) to seroreversion by enzyme-linked immunoabsorbent assay (ELISA) was 50.1 ± 14.8 weeks, or 11.6 months (n = 84); the range of times to antibody loss by ELISA was 17.9 to 82.0 weeks. The mean time to seroreversion by Western blot was 68.3 ± 12.6 weeks, or 15.8 months (n = 51), with a range of 44.9 to 94.1 weeks. Initial anti-human immunodeficiency virus titer as measured by cord blood ELISA optical density (OD) was found to relate significantly to mean time to seroreversion. No relationship to time to seroreversion was demonstrated for gestational age, maternal or neonatal serum immunoglobulin concentrations, maternal CD4 cell counts, maternal alcohol consumption, infantile diarrhea or failure to thrive. The lengthy time to seroreversion seen here demonstrates the 1994 revised Centers for Disease Control and Prevention definition of human immunodeficiency virus infection (based on seropositivity by both ELISA and confirmatory tests persisting beyond 18 months of age) to be accurate in our population. We recommend Western blot testing be used as confirmation for positive ELISAs only after 18 months of age.",
keywords = "Human immunodeficiency virus, natural history, perinatal transmission, seroreversion",
author = "Chantry, {C. J.} and Cooper, {E. R.} and Pelton, {S. I.} and C. Zorilla and Hillyer, {G. V.} and C. Diaz",
year = "1995",
language = "English (US)",
volume = "14",
pages = "382--387",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Seroreversion in human immunodeficiency virus-exposed but uninfected infants

AU - Chantry, C. J.

AU - Cooper, E. R.

AU - Pelton, S. I.

AU - Zorilla, C.

AU - Hillyer, G. V.

AU - Diaz, C.

PY - 1995

Y1 - 1995

N2 - The goal of this study was to describe seroreversion (SR) in a cohort of human immunodeficiency virus-exposed but uninfected infants. Groups of patients who seroreverted very early or late were examined for salient clinical and immunologic characteristics of the mother or infant. The mean time (± s.d.) to seroreversion by enzyme-linked immunoabsorbent assay (ELISA) was 50.1 ± 14.8 weeks, or 11.6 months (n = 84); the range of times to antibody loss by ELISA was 17.9 to 82.0 weeks. The mean time to seroreversion by Western blot was 68.3 ± 12.6 weeks, or 15.8 months (n = 51), with a range of 44.9 to 94.1 weeks. Initial anti-human immunodeficiency virus titer as measured by cord blood ELISA optical density (OD) was found to relate significantly to mean time to seroreversion. No relationship to time to seroreversion was demonstrated for gestational age, maternal or neonatal serum immunoglobulin concentrations, maternal CD4 cell counts, maternal alcohol consumption, infantile diarrhea or failure to thrive. The lengthy time to seroreversion seen here demonstrates the 1994 revised Centers for Disease Control and Prevention definition of human immunodeficiency virus infection (based on seropositivity by both ELISA and confirmatory tests persisting beyond 18 months of age) to be accurate in our population. We recommend Western blot testing be used as confirmation for positive ELISAs only after 18 months of age.

AB - The goal of this study was to describe seroreversion (SR) in a cohort of human immunodeficiency virus-exposed but uninfected infants. Groups of patients who seroreverted very early or late were examined for salient clinical and immunologic characteristics of the mother or infant. The mean time (± s.d.) to seroreversion by enzyme-linked immunoabsorbent assay (ELISA) was 50.1 ± 14.8 weeks, or 11.6 months (n = 84); the range of times to antibody loss by ELISA was 17.9 to 82.0 weeks. The mean time to seroreversion by Western blot was 68.3 ± 12.6 weeks, or 15.8 months (n = 51), with a range of 44.9 to 94.1 weeks. Initial anti-human immunodeficiency virus titer as measured by cord blood ELISA optical density (OD) was found to relate significantly to mean time to seroreversion. No relationship to time to seroreversion was demonstrated for gestational age, maternal or neonatal serum immunoglobulin concentrations, maternal CD4 cell counts, maternal alcohol consumption, infantile diarrhea or failure to thrive. The lengthy time to seroreversion seen here demonstrates the 1994 revised Centers for Disease Control and Prevention definition of human immunodeficiency virus infection (based on seropositivity by both ELISA and confirmatory tests persisting beyond 18 months of age) to be accurate in our population. We recommend Western blot testing be used as confirmation for positive ELISAs only after 18 months of age.

KW - Human immunodeficiency virus

KW - natural history

KW - perinatal transmission

KW - seroreversion

UR - http://www.scopus.com/inward/record.url?scp=0029046767&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029046767&partnerID=8YFLogxK

M3 - Article

C2 - 7638014

VL - 14

SP - 382

EP - 387

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 5

ER -