Serological investigation of Heartland virus (Bunyaviridae: Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013

Angela M. Bosco-Lauth, Nicholas A. Panella, J. Jeffrey Root, Tom Gidlewski, R. Ryan Lash, Jessica R. Harmon, Kristen L. Burkhalter, Marvin S. Godsey, Harry M. Savage, William L. Nicholson, Nicholas Komar, Aaron Brault

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Heartland virus (HRTV; Bunyaviridae: Phlebovirus) has recently emerged as a causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States. The lone star tick (Amblyomma americanum L.) has been implicated as a vector. To identify candidate vertebrate amplification hosts associated with enzootic maintenance of the virus, sera and ticks were sampled from 160 mammals (8 species) and 139 birds (26 species) captured near 2 human case residences in Andrew and Nodaway Counties in northwest Missouri. HRTV-specific neutralizing antibodies were identified in northern raccoons (42.6%), horses (17.4%), white-tailed deer (14.3%), dogs (7.7%), and Virginia opossums (3.8%), but not in birds. Virus isolation attempts from sera and ticks failed to detect HRTV. The high antibody prevalence coupled with local abundance of white-tailed deer and raccoons identifies these species as candidate amplification hosts.

Original languageEnglish (US)
Pages (from-to)1163-1167
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume92
Issue number6
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

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