Serological investigation of Heartland virus (Bunyaviridae: Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013

Angela M. Bosco-Lauth, Nicholas A. Panella, J. Jeffrey Root, Tom Gidlewski, R. Ryan Lash, Jessica R. Harmon, Kristen L. Burkhalter, Marvin S. Godsey, Harry M. Savage, William L. Nicholson, Nicholas Komar, Aaron Brault

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Heartland virus (HRTV; Bunyaviridae: Phlebovirus) has recently emerged as a causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States. The lone star tick (Amblyomma americanum L.) has been implicated as a vector. To identify candidate vertebrate amplification hosts associated with enzootic maintenance of the virus, sera and ticks were sampled from 160 mammals (8 species) and 139 birds (26 species) captured near 2 human case residences in Andrew and Nodaway Counties in northwest Missouri. HRTV-specific neutralizing antibodies were identified in northern raccoons (42.6%), horses (17.4%), white-tailed deer (14.3%), dogs (7.7%), and Virginia opossums (3.8%), but not in birds. Virus isolation attempts from sera and ticks failed to detect HRTV. The high antibody prevalence coupled with local abundance of white-tailed deer and raccoons identifies these species as candidate amplification hosts.

Original languageEnglish (US)
Pages (from-to)1163-1167
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume92
Issue number6
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Phlebovirus
Bunyaviridae
Wild Animals
Domestic Animals
Ticks
Raccoons
Deer
Viruses
Birds
Opossums
Leukopenia
Neutralizing Antibodies
Serum
Thrombocytopenia
Horses
Vertebrates
Mammals
Maintenance
Dogs
Antibodies

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Serological investigation of Heartland virus (Bunyaviridae : Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013. / Bosco-Lauth, Angela M.; Panella, Nicholas A.; Root, J. Jeffrey; Gidlewski, Tom; Lash, R. Ryan; Harmon, Jessica R.; Burkhalter, Kristen L.; Godsey, Marvin S.; Savage, Harry M.; Nicholson, William L.; Komar, Nicholas; Brault, Aaron.

In: American Journal of Tropical Medicine and Hygiene, Vol. 92, No. 6, 01.01.2015, p. 1163-1167.

Research output: Contribution to journalArticle

Bosco-Lauth, AM, Panella, NA, Root, JJ, Gidlewski, T, Lash, RR, Harmon, JR, Burkhalter, KL, Godsey, MS, Savage, HM, Nicholson, WL, Komar, N & Brault, A 2015, 'Serological investigation of Heartland virus (Bunyaviridae: Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013', American Journal of Tropical Medicine and Hygiene, vol. 92, no. 6, pp. 1163-1167. https://doi.org/10.4269/ajtmh.14-0702
Bosco-Lauth, Angela M. ; Panella, Nicholas A. ; Root, J. Jeffrey ; Gidlewski, Tom ; Lash, R. Ryan ; Harmon, Jessica R. ; Burkhalter, Kristen L. ; Godsey, Marvin S. ; Savage, Harry M. ; Nicholson, William L. ; Komar, Nicholas ; Brault, Aaron. / Serological investigation of Heartland virus (Bunyaviridae : Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013. In: American Journal of Tropical Medicine and Hygiene. 2015 ; Vol. 92, No. 6. pp. 1163-1167.
@article{b19c34d6637d484c988aaea04c6a4380,
title = "Serological investigation of Heartland virus (Bunyaviridae: Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013",
abstract = "Heartland virus (HRTV; Bunyaviridae: Phlebovirus) has recently emerged as a causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States. The lone star tick (Amblyomma americanum L.) has been implicated as a vector. To identify candidate vertebrate amplification hosts associated with enzootic maintenance of the virus, sera and ticks were sampled from 160 mammals (8 species) and 139 birds (26 species) captured near 2 human case residences in Andrew and Nodaway Counties in northwest Missouri. HRTV-specific neutralizing antibodies were identified in northern raccoons (42.6{\%}), horses (17.4{\%}), white-tailed deer (14.3{\%}), dogs (7.7{\%}), and Virginia opossums (3.8{\%}), but not in birds. Virus isolation attempts from sera and ticks failed to detect HRTV. The high antibody prevalence coupled with local abundance of white-tailed deer and raccoons identifies these species as candidate amplification hosts.",
author = "Bosco-Lauth, {Angela M.} and Panella, {Nicholas A.} and Root, {J. Jeffrey} and Tom Gidlewski and Lash, {R. Ryan} and Harmon, {Jessica R.} and Burkhalter, {Kristen L.} and Godsey, {Marvin S.} and Savage, {Harry M.} and Nicholson, {William L.} and Nicholas Komar and Aaron Brault",
year = "2015",
month = "1",
day = "1",
doi = "10.4269/ajtmh.14-0702",
language = "English (US)",
volume = "92",
pages = "1163--1167",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "6",

}

TY - JOUR

T1 - Serological investigation of Heartland virus (Bunyaviridae

T2 - Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013

AU - Bosco-Lauth, Angela M.

AU - Panella, Nicholas A.

AU - Root, J. Jeffrey

AU - Gidlewski, Tom

AU - Lash, R. Ryan

AU - Harmon, Jessica R.

AU - Burkhalter, Kristen L.

AU - Godsey, Marvin S.

AU - Savage, Harry M.

AU - Nicholson, William L.

AU - Komar, Nicholas

AU - Brault, Aaron

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Heartland virus (HRTV; Bunyaviridae: Phlebovirus) has recently emerged as a causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States. The lone star tick (Amblyomma americanum L.) has been implicated as a vector. To identify candidate vertebrate amplification hosts associated with enzootic maintenance of the virus, sera and ticks were sampled from 160 mammals (8 species) and 139 birds (26 species) captured near 2 human case residences in Andrew and Nodaway Counties in northwest Missouri. HRTV-specific neutralizing antibodies were identified in northern raccoons (42.6%), horses (17.4%), white-tailed deer (14.3%), dogs (7.7%), and Virginia opossums (3.8%), but not in birds. Virus isolation attempts from sera and ticks failed to detect HRTV. The high antibody prevalence coupled with local abundance of white-tailed deer and raccoons identifies these species as candidate amplification hosts.

AB - Heartland virus (HRTV; Bunyaviridae: Phlebovirus) has recently emerged as a causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States. The lone star tick (Amblyomma americanum L.) has been implicated as a vector. To identify candidate vertebrate amplification hosts associated with enzootic maintenance of the virus, sera and ticks were sampled from 160 mammals (8 species) and 139 birds (26 species) captured near 2 human case residences in Andrew and Nodaway Counties in northwest Missouri. HRTV-specific neutralizing antibodies were identified in northern raccoons (42.6%), horses (17.4%), white-tailed deer (14.3%), dogs (7.7%), and Virginia opossums (3.8%), but not in birds. Virus isolation attempts from sera and ticks failed to detect HRTV. The high antibody prevalence coupled with local abundance of white-tailed deer and raccoons identifies these species as candidate amplification hosts.

UR - http://www.scopus.com/inward/record.url?scp=84930609254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930609254&partnerID=8YFLogxK

U2 - 10.4269/ajtmh.14-0702

DO - 10.4269/ajtmh.14-0702

M3 - Article

C2 - 25870419

AN - SCOPUS:84930609254

VL - 92

SP - 1163

EP - 1167

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 6

ER -