Serologic studies in coccidioidomycosis

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Serologic tests are valuable in the management of patients with suspected or confirmed coccidioidomycosis. Qualitative tests (immunodiffusion, enzyme iramunoassay, or latex particle agglutination) permit detection in the serum of the major antibody responses - coccidioidal IgM in early coccidioidomycosis, and complement fixing (CF) IgG, which appears later and is more persistent. Quantitation of the level (titer) of coccidioidal IgG is useful in prognosis and diagnosis. The preferable antigen for these tests is coccidioidin from the hyphal phase of Coccidioides immitis. When coccidioidal disease has disseminated to an extrapulmonary site, the corresponding fluid - cerebrospinal, synovial, peritoneal (as well as pleural) - can be tested for coccidioidal antibody provided that the serum is known to be positive. Some immuno-compromised patients may have a limited humoral responsiveness; therefore, it will be important to develop a practical method for the detection of coccidioidal antigen.

Original languageEnglish (US)
Pages (from-to)242-250
Number of pages9
JournalSeminars in Respiratory Infections
Volume16
Issue number4
DOIs
StatePublished - 2001

Fingerprint

Coccidioidomycosis
Coccidioidin
Immunoglobulin G
Coccidioides
Antigens
Immunodiffusion
Synovial Fluid
Agglutination
Serologic Tests
Serum
Microspheres
Antibody Formation
Immunoglobulin M
Cerebrospinal Fluid
Antibodies
Enzymes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Microbiology (medical)

Cite this

Serologic studies in coccidioidomycosis. / Pappagianis, Demosthenes.

In: Seminars in Respiratory Infections, Vol. 16, No. 4, 2001, p. 242-250.

Research output: Contribution to journalArticle

@article{3f91095818e24cfba40f0d3442612052,
title = "Serologic studies in coccidioidomycosis",
abstract = "Serologic tests are valuable in the management of patients with suspected or confirmed coccidioidomycosis. Qualitative tests (immunodiffusion, enzyme iramunoassay, or latex particle agglutination) permit detection in the serum of the major antibody responses - coccidioidal IgM in early coccidioidomycosis, and complement fixing (CF) IgG, which appears later and is more persistent. Quantitation of the level (titer) of coccidioidal IgG is useful in prognosis and diagnosis. The preferable antigen for these tests is coccidioidin from the hyphal phase of Coccidioides immitis. When coccidioidal disease has disseminated to an extrapulmonary site, the corresponding fluid - cerebrospinal, synovial, peritoneal (as well as pleural) - can be tested for coccidioidal antibody provided that the serum is known to be positive. Some immuno-compromised patients may have a limited humoral responsiveness; therefore, it will be important to develop a practical method for the detection of coccidioidal antigen.",
author = "Demosthenes Pappagianis",
year = "2001",
doi = "10.1053/srin.2001.29315",
language = "English (US)",
volume = "16",
pages = "242--250",
journal = "Seminars in Respiratory Infections",
issn = "0882-0546",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Serologic studies in coccidioidomycosis

AU - Pappagianis, Demosthenes

PY - 2001

Y1 - 2001

N2 - Serologic tests are valuable in the management of patients with suspected or confirmed coccidioidomycosis. Qualitative tests (immunodiffusion, enzyme iramunoassay, or latex particle agglutination) permit detection in the serum of the major antibody responses - coccidioidal IgM in early coccidioidomycosis, and complement fixing (CF) IgG, which appears later and is more persistent. Quantitation of the level (titer) of coccidioidal IgG is useful in prognosis and diagnosis. The preferable antigen for these tests is coccidioidin from the hyphal phase of Coccidioides immitis. When coccidioidal disease has disseminated to an extrapulmonary site, the corresponding fluid - cerebrospinal, synovial, peritoneal (as well as pleural) - can be tested for coccidioidal antibody provided that the serum is known to be positive. Some immuno-compromised patients may have a limited humoral responsiveness; therefore, it will be important to develop a practical method for the detection of coccidioidal antigen.

AB - Serologic tests are valuable in the management of patients with suspected or confirmed coccidioidomycosis. Qualitative tests (immunodiffusion, enzyme iramunoassay, or latex particle agglutination) permit detection in the serum of the major antibody responses - coccidioidal IgM in early coccidioidomycosis, and complement fixing (CF) IgG, which appears later and is more persistent. Quantitation of the level (titer) of coccidioidal IgG is useful in prognosis and diagnosis. The preferable antigen for these tests is coccidioidin from the hyphal phase of Coccidioides immitis. When coccidioidal disease has disseminated to an extrapulmonary site, the corresponding fluid - cerebrospinal, synovial, peritoneal (as well as pleural) - can be tested for coccidioidal antibody provided that the serum is known to be positive. Some immuno-compromised patients may have a limited humoral responsiveness; therefore, it will be important to develop a practical method for the detection of coccidioidal antigen.

UR - http://www.scopus.com/inward/record.url?scp=0035667667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035667667&partnerID=8YFLogxK

U2 - 10.1053/srin.2001.29315

DO - 10.1053/srin.2001.29315

M3 - Article

C2 - 11740825

AN - SCOPUS:0035667667

VL - 16

SP - 242

EP - 250

JO - Seminars in Respiratory Infections

JF - Seminars in Respiratory Infections

SN - 0882-0546

IS - 4

ER -