Serologic response of harbor seals (Phoca Vitulina) to vaccination with a recombinant canine distemper vaccine

Nina Quinley, Jonna A Mazet, Rebecca Rivera, Todd L. Schmitt, Christopher Dold, James McBain, Virginia Fritsch, Pamela K. Yochem

Research output: Contribution to journalArticle

6 Scopus citations


Morbilliviruses pose a significant threat to marine mammal populations around the world and have been associated with multiple epizootics in pinnipeds and cetaceans. As part of a preventive veterinary medical program, five harbor seals (Phoca vitulina) in a managed collection were vaccinated with a recombinant canarypox-vectored canine distemper virus vaccine. The vaccine was evaluated for safety (by monitoring seals for local and systemic adverse effects and by testing for shedding of the canarypox vector) and efficacy (by testing for serum neutralizing antibodies). None of the seals showed signs of local or systemic adverse reactions to the vaccination. Three seals vaccinated once did not seroconvert, but the recombinant vaccine induced a persistent serum virus neutralizing titer (12 mo) in the two seals that were vaccinated twice, 1 mo apart.

Original languageEnglish (US)
Pages (from-to)579-586
Number of pages8
JournalJournal of Wildlife Diseases
Issue number3
StatePublished - Jul 1 2013



  • Canarypox vectored
  • Canine distemper virus
  • Harbor seals
  • Morbillivirus
  • Vaccine

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

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