Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California

Michele T Jay-Russell, Michael S. Ascher, Bruno B Chomel, Minoo Madon, David Sesline, Barryett A. Enge, Brian Hjelle, Thomas G. Ksiazek, Pierre E. Rollin, Philip H Kass, Kevin Reilly

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40 Scopus citations


A total of 4,626 mammals were serologically tested for antibodies to Sin Nombre virus. All nonrodent species were antibody negative. Among wild rodents, antibody prevalence was 8.5% in murids, 1.4% in heteromyids, and < 0.1% in sciurids. Of 1,921 Peromyscus maniculatus (deer mice), 226 (11.8%) were antibody positive, including one collected in 1975. The highest antibody prevalence (71.4% of 35) was found among P. maniculatus on Santa Cruz Island, off the southern California coast. Prevalence of antibodies among deer mice trapped near sites of human cases (26.8% of 164) was significantly higher than that of mice from other sites (odds ratio = 4.5; 95% confidence interval = 1.7, 11.6). Antibody prevalence increased with rising elevation (>1,200 meters) and correlated with a spatial cluster of hantavirus pulmonary syndrome cases in the Sierra Nevada.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalEmerging Infectious Diseases
Issue number2
StatePublished - 1997

ASJC Scopus subject areas

  • Microbiology (medical)


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