Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California

Michele T Jay-Russell, Michael S. Ascher, Bruno B Chomel, Minoo Madon, David Sesline, Barryett A. Enge, Brian Hjelle, Thomas G. Ksiazek, Pierre E. Rollin, Philip H Kass, Kevin Reilly

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Abstract

A total of 4,626 mammals were serologically tested for antibodies to Sin Nombre virus. All nonrodent species were antibody negative. Among wild rodents, antibody prevalence was 8.5% in murids, 1.4% in heteromyids, and < 0.1% in sciurids. Of 1,921 Peromyscus maniculatus (deer mice), 226 (11.8%) were antibody positive, including one collected in 1975. The highest antibody prevalence (71.4% of 35) was found among P. maniculatus on Santa Cruz Island, off the southern California coast. Prevalence of antibodies among deer mice trapped near sites of human cases (26.8% of 164) was significantly higher than that of mice from other sites (odds ratio = 4.5; 95% confidence interval = 1.7, 11.6). Antibody prevalence increased with rising elevation (>1,200 meters) and correlated with a spatial cluster of hantavirus pulmonary syndrome cases in the Sierra Nevada.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalEmerging Infectious Diseases
Volume3
Issue number2
StatePublished - 1997

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Hantavirus Infections
Seroepidemiologic Studies
Rodentia
Antibodies
Sin Nombre virus
Hantavirus Pulmonary Syndrome
Muridae
Mammals

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Jay-Russell, M. T., Ascher, M. S., Chomel, B. B., Madon, M., Sesline, D., Enge, B. A., ... Reilly, K. (1997). Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California. Emerging Infectious Diseases, 3(2), 183-190.

Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California. / Jay-Russell, Michele T; Ascher, Michael S.; Chomel, Bruno B; Madon, Minoo; Sesline, David; Enge, Barryett A.; Hjelle, Brian; Ksiazek, Thomas G.; Rollin, Pierre E.; Kass, Philip H; Reilly, Kevin.

In: Emerging Infectious Diseases, Vol. 3, No. 2, 1997, p. 183-190.

Research output: Contribution to journalArticle

Jay-Russell, MT, Ascher, MS, Chomel, BB, Madon, M, Sesline, D, Enge, BA, Hjelle, B, Ksiazek, TG, Rollin, PE, Kass, PH & Reilly, K 1997, 'Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California', Emerging Infectious Diseases, vol. 3, no. 2, pp. 183-190.
Jay-Russell MT, Ascher MS, Chomel BB, Madon M, Sesline D, Enge BA et al. Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California. Emerging Infectious Diseases. 1997;3(2):183-190.
Jay-Russell, Michele T ; Ascher, Michael S. ; Chomel, Bruno B ; Madon, Minoo ; Sesline, David ; Enge, Barryett A. ; Hjelle, Brian ; Ksiazek, Thomas G. ; Rollin, Pierre E. ; Kass, Philip H ; Reilly, Kevin. / Seroepidemiologic Studies of Hantavirus Infection among Wild Rodents in California. In: Emerging Infectious Diseases. 1997 ; Vol. 3, No. 2. pp. 183-190.
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