Serine utilization in mouse liver: Influence of caloric restriction and aging

Kevork Hagopian, Jon J Ramsey, Richard Weindruch

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The influence of caloric restriction (CR) on the activities of hepatic serine metabolizing enzymes in young (3 months) and old (30 months) mice was studied. Serine dehydratase (SDH) activity increased markedly with age in both diet groups and in old mice was higher in the CR group. No effects of CR were observed in the young. Serine:pyruvate transaminase (SPT) and glycerate kinase activities were unaffected by age and diet. However, glycerate dehydrogenase activity was decreased in old CR mice but not in young CR. The results of this study show that long-term CR influenced serine utilization only in the pathway catalyzed by SDH. This suggests that in mouse liver this pathway is critical for serine utilization in gluconeogenesis, while the SPT pathway plays a minor role. The increase in SDH activity with long-term CR is consistent with sustained increase in gluconeogenesis.

Original languageEnglish (US)
Pages (from-to)2009-2013
Number of pages5
JournalFEBS Letters
Issue number9
StatePublished - Mar 28 2005


  • Caloric restriction
  • Glycerate dehydrogenase
  • Glycerate kinase
  • Serine dehydratase
  • Serine:pyruvate transaminase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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