Sequential two-step multienzyme synthesis of tumor-associated sialyl T-antigens and derivatives

Kam Lau; Hai Yu; Vireak Thon; Zahra Khedri; Meghan E. Leon; Bao K. Tran; Xi Chen

doi:10.1039/c0ob01269f

Sequential two-step multienzyme synthesis of tumor-associated sialyl T-antigens and derivatives

Kam Lau, Hai Yu, Vireak Thon, Zahra Khedri, Meghan E. Leon, Bao K. Tran, Xi Chen

Chemistry

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A series of α2-3-sialylated β1-3-linked galactosides, including sialyl T-antigens, 3′-sialyl galacto-N-biose, 3′-sialyl lacto-N-biose, and their derivatives containing natural and non-natural sialic acid forms have been synthesized from simple monosaccharides using an efficient sequential two-step multienzyme approach.

Original language	English (US)
Pages (from-to)	2784-2789
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	8
DOIs	https://doi.org/10.1039/c0ob01269f
State	Published - Apr 21 2011

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry

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abstract = "A series of α2-3-sialylated β1-3-linked galactosides, including sialyl T-antigens, 3′-sialyl galacto-N-biose, 3′-sialyl lacto-N-biose, and their derivatives containing natural and non-natural sialic acid forms have been synthesized from simple monosaccharides using an efficient sequential two-step multienzyme approach.",

author = "Kam Lau and Hai Yu and Vireak Thon and Zahra Khedri and Leon, {Meghan E.} and Tran, {Bao K.} and Xi Chen",

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AU - Lau, Kam

AU - Yu, Hai

AU - Thon, Vireak

AU - Khedri, Zahra

AU - Leon, Meghan E.

AU - Tran, Bao K.

AU - Chen, Xi

PY - 2011/4/21

Y1 - 2011/4/21

N2 - A series of α2-3-sialylated β1-3-linked galactosides, including sialyl T-antigens, 3′-sialyl galacto-N-biose, 3′-sialyl lacto-N-biose, and their derivatives containing natural and non-natural sialic acid forms have been synthesized from simple monosaccharides using an efficient sequential two-step multienzyme approach.

AB - A series of α2-3-sialylated β1-3-linked galactosides, including sialyl T-antigens, 3′-sialyl galacto-N-biose, 3′-sialyl lacto-N-biose, and their derivatives containing natural and non-natural sialic acid forms have been synthesized from simple monosaccharides using an efficient sequential two-step multienzyme approach.

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JF - Organic and Biomolecular Chemistry

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ER -

Sequential two-step multienzyme synthesis of tumor-associated sialyl T-antigens and derivatives

Abstract

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