Sequential two-step multienzyme synthesis of tumor-associated sialyl T-antigens and derivatives

Kam Lau, Hai Yu, Vireak Thon, Zahra Khedri, Meghan E. Leon, Bao K. Tran, Xi Chen

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A series of α2-3-sialylated β1-3-linked galactosides, including sialyl T-antigens, 3′-sialyl galacto-N-biose, 3′-sialyl lacto-N-biose, and their derivatives containing natural and non-natural sialic acid forms have been synthesized from simple monosaccharides using an efficient sequential two-step multienzyme approach.

Original languageEnglish (US)
Pages (from-to)2784-2789
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number8
DOIs
StatePublished - Apr 21 2011

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

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