Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp

Tamas Banyasz; Balazs Horvath; Zhong Jian; Leighton T Izu; Ye Chen-Izu

doi:10.1016/j.yjmcc.2010.12.020

Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp

Tamas Banyasz, Balazs Horvath, Zhong Jian, Leighton T Izu, Ye Chen-Izu

Pharmacology

Research output: Contribution to journal › Article

36 Scopus citations

Abstract

The cardiac action potential (AP) is shaped by myriad ionic currents. In this study, we develop an innovative AP-clamp Sequential Dissection technique to enable the recording of multiple ionic currents in the single cell under AP-clamp. This new technique presents a significant step beyond the traditional way of recording only one current in any one cell. The ability to measure many currents in a single cell has revealed two hitherto unknown characteristics of the ionic currents in cardiac cells: coordination of currents within a cell and large variation of currents between cells. Hence, the AP-clamp Sequential Dissection method provides a unique and powerful tool for studying individual cell electrophysiology.

Original language	English (US)
Pages (from-to)	578-581
Number of pages	4
Journal	Journal of Molecular and Cellular Cardiology
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.yjmcc.2010.12.020
State	Published - Mar 2011

Keywords

Action potential
AP-clamp
Arrhythmia
Ca channel
Cardiac
K channel

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

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Banyasz, T., Horvath, B., Jian, Z., Izu, L. T., & Chen-Izu, Y. (2011). Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp. Journal of Molecular and Cellular Cardiology, 50(3), 578-581. https://doi.org/10.1016/j.yjmcc.2010.12.020

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