Abstract
The cardiac action potential (AP) is shaped by myriad ionic currents. In this study, we develop an innovative AP-clamp Sequential Dissection technique to enable the recording of multiple ionic currents in the single cell under AP-clamp. This new technique presents a significant step beyond the traditional way of recording only one current in any one cell. The ability to measure many currents in a single cell has revealed two hitherto unknown characteristics of the ionic currents in cardiac cells: coordination of currents within a cell and large variation of currents between cells. Hence, the AP-clamp Sequential Dissection method provides a unique and powerful tool for studying individual cell electrophysiology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 578-581 |
| Number of pages | 4 |
| Journal | Journal of Molecular and Cellular Cardiology |
| Volume | 50 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2011 |
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Keywords
- Action potential
- AP-clamp
- Arrhythmia
- Ca channel
- Cardiac
- K channel
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine
Cite this
Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp. / Banyasz, Tamas; Horvath, Balazs; Jian, Zhong; Izu, Leighton T; Chen-Izu, Ye.
In: Journal of Molecular and Cellular Cardiology, Vol. 50, No. 3, 03.2011, p. 578-581.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp
AU - Banyasz, Tamas
AU - Horvath, Balazs
AU - Jian, Zhong
AU - Izu, Leighton T
AU - Chen-Izu, Ye
PY - 2011/3
Y1 - 2011/3
N2 - The cardiac action potential (AP) is shaped by myriad ionic currents. In this study, we develop an innovative AP-clamp Sequential Dissection technique to enable the recording of multiple ionic currents in the single cell under AP-clamp. This new technique presents a significant step beyond the traditional way of recording only one current in any one cell. The ability to measure many currents in a single cell has revealed two hitherto unknown characteristics of the ionic currents in cardiac cells: coordination of currents within a cell and large variation of currents between cells. Hence, the AP-clamp Sequential Dissection method provides a unique and powerful tool for studying individual cell electrophysiology.
AB - The cardiac action potential (AP) is shaped by myriad ionic currents. In this study, we develop an innovative AP-clamp Sequential Dissection technique to enable the recording of multiple ionic currents in the single cell under AP-clamp. This new technique presents a significant step beyond the traditional way of recording only one current in any one cell. The ability to measure many currents in a single cell has revealed two hitherto unknown characteristics of the ionic currents in cardiac cells: coordination of currents within a cell and large variation of currents between cells. Hence, the AP-clamp Sequential Dissection method provides a unique and powerful tool for studying individual cell electrophysiology.
KW - Action potential
KW - AP-clamp
KW - Arrhythmia
KW - Ca channel
KW - Cardiac
KW - K channel
UR - http://www.scopus.com/inward/record.url?scp=79551587546&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551587546&partnerID=8YFLogxK
U2 - 10.1016/j.yjmcc.2010.12.020
DO - 10.1016/j.yjmcc.2010.12.020
M3 - Article
VL - 50
SP - 578
EP - 581
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
SN - 0022-2828
IS - 3
ER -