Sequential dependence of freeze-drying and irradiation on biomechanical properties of rat bone.

R Randall, Richard R. Pelker, Gary E. Friedlaender, Seth L. Goldsmith, Manohar M. Panjabi

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Femurs of Sprague-Dawley rats were subjected to in vitro 3-Mrad irradiation and/or freeze-drying to investigate whether these processes have an order-dependent effect on the biomechanical properties of bone. Four experimental groups were designated-irradiated (RAD); freeze-dried (FD); irradiated, then freeze-dried (RAD/FD); and freeze-dried, then irradiated (FD/RAD). After the various treatments, the bones were inspected for microfractures and then torsion-tested. Microfractures were seen in more than 90% of the specimens that had undergone freeze-drying alone or with irradiation. Regarding the normalized relative ratios of torque, there was a statistically significant difference (P < .05) between the RAD group (1.0) and the 3 other groups (FD, .32; RAD/FD, .40; FD/RAD, .14). Differences among the FD, RAD/FD, and FD/RAD groups were not significant. However, a trend was bones were weaker than FD and noted: FD/RAD RAD/FD bones.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalAmerican journal of orthopedics (Belle Mead, N.J.)
Issue number3
StatePublished - Mar 1 2002
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

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