Sequential dependence of freeze-drying and irradiation on biomechanical properties of rat bone.

R Randall, Richard R. Pelker, Gary E. Friedlaender, Seth L. Goldsmith, Manohar M. Panjabi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Femurs of Sprague-Dawley rats were subjected to in vitro 3-Mrad irradiation and/or freeze-drying to investigate whether these processes have an order-dependent effect on the biomechanical properties of bone. Four experimental groups were designated-irradiated (RAD); freeze-dried (FD); irradiated, then freeze-dried (RAD/FD); and freeze-dried, then irradiated (FD/RAD). After the various treatments, the bones were inspected for microfractures and then torsion-tested. Microfractures were seen in more than 90% of the specimens that had undergone freeze-drying alone or with irradiation. Regarding the normalized relative ratios of torque, there was a statistically significant difference (P < .05) between the RAD group (1.0) and the 3 other groups (FD, .32; RAD/FD, .40; FD/RAD, .14). Differences among the FD, RAD/FD, and FD/RAD groups were not significant. However, a trend was bones were weaker than FD and noted: FD/RAD RAD/FD bones.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalAmerican journal of orthopedics (Belle Mead, N.J.)
Volume31
Issue number3
StatePublished - Mar 1 2002
Externally publishedYes

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Freeze Drying
Bone and Bones
Stress Fractures
Torque
Femur
Sprague Dawley Rats
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sequential dependence of freeze-drying and irradiation on biomechanical properties of rat bone. / Randall, R; Pelker, Richard R.; Friedlaender, Gary E.; Goldsmith, Seth L.; Panjabi, Manohar M.

In: American journal of orthopedics (Belle Mead, N.J.), Vol. 31, No. 3, 01.03.2002, p. 129-134.

Research output: Contribution to journalArticle

Randall, R ; Pelker, Richard R. ; Friedlaender, Gary E. ; Goldsmith, Seth L. ; Panjabi, Manohar M. / Sequential dependence of freeze-drying and irradiation on biomechanical properties of rat bone. In: American journal of orthopedics (Belle Mead, N.J.). 2002 ; Vol. 31, No. 3. pp. 129-134.
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