Sequential administration of cyclophosphamide and granulocyte-colony stimulating factor relieves impaired myeloid maturation in Felty's syndrome

J. S. Pixley, Ken Y Yoneda, P. B. Manalo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A patient with Felty's syndrome (FS) and persistent profound neutropenia developed recurrent infections and sepsis syndrome. No impairment of granulocyte-macrophage colony development was observed in vitro. Marrow morphology revealed an absence of mature neutrophil forms despite administration of granulocyte-colony stimulating factor (G-CSF). However, pretreatment with bolus cyclophosphamide (CY) permitted the growth factor to relieve this impairment of late myeloid maturation and resulted in a brisk, albeit short, burst of neutrophilia. This suggests that immune interference in myelopoiesis can be overcome by growth factor administration if immune activity is adequately dampened by immunosuppressive therapy.

Original languageEnglish (US)
Pages (from-to)304-306
Number of pages3
JournalAmerican Journal of Hematology
Volume43
Issue number4
StatePublished - 1993
Externally publishedYes

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Felty Syndrome
Granulocyte Colony-Stimulating Factor
Cyclophosphamide
Intercellular Signaling Peptides and Proteins
Myelopoiesis
Systemic Inflammatory Response Syndrome
Immunosuppressive Agents
Neutropenia
Granulocytes
Neutrophils
Bone Marrow
Macrophages
Infection
Therapeutics

Keywords

  • hematopoietic growth factors
  • immune mediated neutropenia
  • immunosuppressive therapy

ASJC Scopus subject areas

  • Hematology

Cite this

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AU - Yoneda, Ken Y

AU - Manalo, P. B.

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AB - A patient with Felty's syndrome (FS) and persistent profound neutropenia developed recurrent infections and sepsis syndrome. No impairment of granulocyte-macrophage colony development was observed in vitro. Marrow morphology revealed an absence of mature neutrophil forms despite administration of granulocyte-colony stimulating factor (G-CSF). However, pretreatment with bolus cyclophosphamide (CY) permitted the growth factor to relieve this impairment of late myeloid maturation and resulted in a brisk, albeit short, burst of neutrophilia. This suggests that immune interference in myelopoiesis can be overcome by growth factor administration if immune activity is adequately dampened by immunosuppressive therapy.

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