Abstract
A patient with Felty's syndrome (FS) and persistent profound neutropenia developed recurrent infections and sepsis syndrome. No impairment of granulocyte-macrophage colony development was observed in vitro. Marrow morphology revealed an absence of mature neutrophil forms despite administration of granulocyte-colony stimulating factor (G-CSF). However, pretreatment with bolus cyclophosphamide (CY) permitted the growth factor to relieve this impairment of late myeloid maturation and resulted in a brisk, albeit short, burst of neutrophilia. This suggests that immune interference in myelopoiesis can be overcome by growth factor administration if immune activity is adequately dampened by immunosuppressive therapy.
Original language | English (US) |
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Pages (from-to) | 304-306 |
Number of pages | 3 |
Journal | American Journal of Hematology |
Volume | 43 |
Issue number | 4 |
State | Published - 1993 |
Externally published | Yes |
Keywords
- hematopoietic growth factors
- immune mediated neutropenia
- immunosuppressive therapy
ASJC Scopus subject areas
- Hematology