Sequential administration of cyclophosphamide and granulocyte-colony stimulating factor relieves impaired myeloid maturation in Felty's syndrome

J. S. Pixley, Ken Y Yoneda, P. B. Manalo

Research output: Contribution to journalArticle

13 Scopus citations


A patient with Felty's syndrome (FS) and persistent profound neutropenia developed recurrent infections and sepsis syndrome. No impairment of granulocyte-macrophage colony development was observed in vitro. Marrow morphology revealed an absence of mature neutrophil forms despite administration of granulocyte-colony stimulating factor (G-CSF). However, pretreatment with bolus cyclophosphamide (CY) permitted the growth factor to relieve this impairment of late myeloid maturation and resulted in a brisk, albeit short, burst of neutrophilia. This suggests that immune interference in myelopoiesis can be overcome by growth factor administration if immune activity is adequately dampened by immunosuppressive therapy.

Original languageEnglish (US)
Pages (from-to)304-306
Number of pages3
JournalAmerican Journal of Hematology
Issue number4
StatePublished - 1993
Externally publishedYes



  • hematopoietic growth factors
  • immune mediated neutropenia
  • immunosuppressive therapy

ASJC Scopus subject areas

  • Hematology

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