Abstract
A patient with Felty's syndrome (FS) and persistent profound neutropenia developed recurrent infections and sepsis syndrome. No impairment of granulocyte-macrophage colony development was observed in vitro. Marrow morphology revealed an absence of mature neutrophil forms despite administration of granulocyte-colony stimulating factor (G-CSF). However, pretreatment with bolus cyclophosphamide (CY) permitted the growth factor to relieve this impairment of late myeloid maturation and resulted in a brisk, albeit short, burst of neutrophilia. This suggests that immune interference in myelopoiesis can be overcome by growth factor administration if immune activity is adequately dampened by immunosuppressive therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 304-306 |
| Number of pages | 3 |
| Journal | American Journal of Hematology |
| Volume | 43 |
| Issue number | 4 |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- hematopoietic growth factors
- immune mediated neutropenia
- immunosuppressive therapy
ASJC Scopus subject areas
- Hematology
Cite this
Sequential administration of cyclophosphamide and granulocyte-colony stimulating factor relieves impaired myeloid maturation in Felty's syndrome. / Pixley, J. S.; Yoneda, Ken Y; Manalo, P. B.
In: American Journal of Hematology, Vol. 43, No. 4, 1993, p. 304-306.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sequential administration of cyclophosphamide and granulocyte-colony stimulating factor relieves impaired myeloid maturation in Felty's syndrome
AU - Pixley, J. S.
AU - Yoneda, Ken Y
AU - Manalo, P. B.
PY - 1993
Y1 - 1993
N2 - A patient with Felty's syndrome (FS) and persistent profound neutropenia developed recurrent infections and sepsis syndrome. No impairment of granulocyte-macrophage colony development was observed in vitro. Marrow morphology revealed an absence of mature neutrophil forms despite administration of granulocyte-colony stimulating factor (G-CSF). However, pretreatment with bolus cyclophosphamide (CY) permitted the growth factor to relieve this impairment of late myeloid maturation and resulted in a brisk, albeit short, burst of neutrophilia. This suggests that immune interference in myelopoiesis can be overcome by growth factor administration if immune activity is adequately dampened by immunosuppressive therapy.
AB - A patient with Felty's syndrome (FS) and persistent profound neutropenia developed recurrent infections and sepsis syndrome. No impairment of granulocyte-macrophage colony development was observed in vitro. Marrow morphology revealed an absence of mature neutrophil forms despite administration of granulocyte-colony stimulating factor (G-CSF). However, pretreatment with bolus cyclophosphamide (CY) permitted the growth factor to relieve this impairment of late myeloid maturation and resulted in a brisk, albeit short, burst of neutrophilia. This suggests that immune interference in myelopoiesis can be overcome by growth factor administration if immune activity is adequately dampened by immunosuppressive therapy.
KW - hematopoietic growth factors
KW - immune mediated neutropenia
KW - immunosuppressive therapy
UR - http://www.scopus.com/inward/record.url?scp=0027216671&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027216671&partnerID=8YFLogxK
M3 - Article
C2 - 7690520
AN - SCOPUS:0027216671
VL - 43
SP - 304
EP - 306
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 4
ER -