Sequence-specific DNA binding by the v-erbA oncogene protein of avian erythroblastosis virus

Beverly Geary Bonde, Martin L. Privalsky

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The v-erbA oncogene, a transduced copy of a thyroid hormone receptor, plays an important role in establishment of the transformed cell phenotype induced by avian erythroblastosis virus. The ability of thyroid hormone receptors to bind to specific sites on chromatin and to thereby modify the expression of adjacent target genes is a crucial element in their mechanism of action in the normal cell. The v-erbA protein also bound at high affinity to a set of DNA fragments recognized by the rat thyroid hormone receptor, but the relative affinity of the v-erbA protein for the different binding sites was distinct from that previously reported for the thyroid hormone receptors.

Original languageEnglish (US)
Pages (from-to)1314-1320
Number of pages7
JournalJournal of Virology
Volume64
Issue number3
StatePublished - 1990

ASJC Scopus subject areas

  • Immunology

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