Sequence similarity of putative transposases links the maize Mutator autonomous element and a group of bacterial insertion sequences

Jonathan A Eisen, Maria Ines Benito, Virginia Walbot

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

The Mutator transposable element system of maize is the most active transposable element system characterized in higher plants. While Mutator has been used to generate and tag thousands of new maize mutants, the mechanism and regulation of its transposition are poorly understood. The Mutator autonomous element, MuDR, encodes two proteins: MURA and MURB. We have detected an amino acid sequence motif shared by MURA and the putative transposases of a group of bacterial insertion sequences. Based on this similarity we believe that MURA is the transposase of the Mutator system. In addition we have detected two rice cDNAs in genbank with extensive similarity to MURA. This sequence similarity suggests that a Mutator-like element is present in rice. We believe that Mutator, a group of bacterial insertion sequences, and an uncharacterized rice transposon represent members of a family of transposable elements.

Original languageEnglish (US)
Pages (from-to)2634-2636
Number of pages3
JournalNucleic Acids Research
Volume22
Issue number13
StatePublished - Jul 11 1994
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)

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