Sequence and variability of the 5.85 and 26S rRNA genes of Pneumocystis carinii

Yong Liu, Marissa Rocourt, Sueihua Pan, Chientzu Liu, Michael J Leibowitz

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


The sequence of the coding region of the rRNA operon of rat-derived Pneumocystis carinii has been completed, including the genes for 5.8S and 26S rRNA. These genes show homology to the rRNA genes of yeast, and an apparent group I self-splicing intron is present in the 26S rRNA gene. Like a similar intron in the 16S rRNA gene, this intron is in a phylogenetically conserved region. Variation in the 26S rRNA sequence was noted between P.carinii organisms isolated from two different sources.

Original languageEnglish (US)
Pages (from-to)3763-3772
Number of pages10
JournalNucleic Acids Research
Issue number14
StatePublished - Jul 25 1992
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)


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