Sequence analysis of the βB2-crystallin cDNA of hamster containing a domain conserved among vertebrates

Konstantinos Zarbalis, Bimal Chatterjee, Jana Löster, Thomas Werner, Jochen Graw

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The cDNA sequence of the βB2-cry was determined from hamster (Mesocricetus auratus) and compared to the corresponding genes of bovine, frog, chicken, human, mouse and rat. Multispecies comparison demonstrated high homology between the hamster, rat and mouse gene, but larger distances to man, bovine, chicken and frog. There is striking identity within a strech of 36 deduced amino acids (aa) between the Greek key motif 3 and part of motif 4. This 36-aa domain contains a putative phosphorylation site for protein kinase C and is highly conserved among all known basic βB-Cry; however, it can neither be detected in the acidic βA- nor in the γ-Cry.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalGene
Volume174
Issue number1
DOIs
StatePublished - Sep 26 1996
Externally publishedYes

Keywords

  • DNA sequence analysis
  • Evolution
  • Eye protein
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Genetics

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