Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome

H. Schaumburg, J. Kaplan, A. Windebank, N. Vick, S. Rasmus, David E Pleasure, M. J. Brown

Research output: Contribution to journalArticlepeer-review

519 Scopus citations


We describe seven adults who had ataxia and severe sensory-nervous-system dysfunction after daily high-level pyridoxine (vitamin B6) consumption. Four were severely disabled; all improved after withdrawal. Weakness was not a feature of this condition, and the central nervous system was clinically spared. Although consumption of large doses of pyridoxine has gained wide public acceptance, this report indicates that it can cause sensory neuropathy or neuronopathy syndromes and that safe guidelines should be established for the use of this widely abused vitamin.

Original languageEnglish (US)
Pages (from-to)445-448
Number of pages4
JournalNew England Journal of Medicine
Issue number8
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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