Sensory mechanisms: Transmitters, modulators and reflexes

Helen E Raybould, H. J. Cooke, F. L. Christofi

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


The enteric nervous system in combination with inputs from parasympathetic and sympathetic nerves regulate the contractile, secretory and vasomotor activity of the gastrointestinal track via neural reflexes. Sensory elements which may be present in specialized neurones, enteroendocrine cells or mast cells detect changes in force, chemical composition or even foreign antigens. Sensory elements signal the enteric nervous system to correct these changes by altering contractile activity, secretion and blood flow. Advances have been made in understanding the sensory mechanisms that are involved in 5-hydroxytryptamine (5-HT) release from enterochromaffin cells (EC) or a model for EC cells. These advances relate to roles for ATP and its metabolites ADP and adenosine in mechanotransduction and a role for a sodium glucose cotransporter, a SGLT-like protein, in chemotransduction.

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalNeurogastroenterology and Motility
Issue numberSUPPL. 1
StatePublished - Apr 2004


  • Adenosine
  • Enteroendocrine cells
  • Purinergic receptors
  • Serotonin

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)


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