Sensitivity of ovine choroid plexus cells to human and other animal interferons

Tilahun Yilma

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The sensitivity of ovine choroid plexus cells to the antiviral effects of the three major types of human and other animal interferons (IFNs) was tested. Ovine cells were found to be highly sensitive to the antiviral effects of natural human IFN-α and IFN-β but not IFN-γ. In addition, ovine cells were highly sensitive to recombinant DNA-derived human IFN-α2, IFN-β1 and IFN-γ. Furthermore, ovine cells were more sensitive (P < 0.01) to human INF-αs than human fibroblasts (trisomic or disomic for chromosome 21) or bovine cells. Moreover, ovine cells were found to be highly sensitive to the three natural types of bovine, caprine, equine and porcine IFN preparations and relatively insensitive to mouse L-cell IFN.

Original languageEnglish (US)
Pages (from-to)2013-2016
Number of pages4
JournalJournal of General Virology
Volume64
Issue number9
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Virology

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